Primary and secondary bone lymphomas

Highlights • Three clinical forms of bone lymphoma exist: the primary, the polyostotic and the secondary bone lymphoma. • Level of evidence supporting therapeutic decisions in these rare tumors is low, and prospective trials appear unrealistic. • This review is based on the analysis of the largest available database of bone lymphomas and of relevant literature. • We provide recommendations for diagnosis, staging and treatment of patients with bone lymphoma in everyday practice. • Special conditions like pathological fractures, indolent lymphomas and central nervous system prophylaxis are also discussed.