General CuBr2-catalyzed highly enantioselective approach for optically active allenols from terminal alkynols

Here, we show a CuBr2-catalyzed approach for a highly enantioselective synthesis (93-99% ee) of allenols from aldehydes and terminal alkynols with the absolute configuration being controlled by applying readily available (R)- or (S)-α,α-diphenylprolinol.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2015-04, Vol.51 (32), p.6956-6959
Hauptverfasser:	Huang, Xin, Cao, Tao, Han, Yulin, Jiang, Xingguo, Lin, Weilong, Zhang, Jiasheng, Ma, Shengming
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkenes - chemistry Alkynes - chemistry Bromides - chemistry Catalysis Copper - chemistry Optical Phenomena Stereoisomerism
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Here, we show a CuBr2-catalyzed approach for a highly enantioselective synthesis (93-99% ee) of allenols from aldehydes and terminal alkynols with the absolute configuration being controlled by applying readily available (R)- or (S)-α,α-diphenylprolinol.
ISSN:	1364-548X
DOI:	10.1039/c5cc00697j