A Noisy Tug of War: The Battle between Transcript Production and Degradation in the Liver

A Noisy Tug of War: The Battle between Transcript Production and Degradation in the Liver

Genetically identical cells in culture often exhibit significant variations, or noise, in gene expression, largely due to transcriptional bursting. Halpern et al. (2015) have developed methods to study gene bursting in tissues to find that this transcriptional bursting also occurs in the mammalian l...

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Veröffentlicht in:Developmental cell 2015-04, Vol.33 (1), p.3-4
Hauptverfasser: Lam, Alec, Deans, Tara L.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Gene Expression Regulation
Hepatocytes - metabolism
Liver - metabolism
Male
RNA, Messenger - genetics
Transcription, Genetic
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Zusammenfassung:Genetically identical cells in culture often exhibit significant variations, or noise, in gene expression, largely due to transcriptional bursting. Halpern et al. (2015) have developed methods to study gene bursting in tissues to find that this transcriptional bursting also occurs in the mammalian liver and may contribute to functional plasticity in hepatocytes.
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2015.03.019