TELEOCIDINS AND BENZOLACTAMS INHIBIT CELL KILLING BY HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1)

Teleocidin B-4 and structurally related synthetic benzolactams were found to be potent inhibitors of cell killing by HIV-1. One of the benzolactams, (-)-BL-V8-310, showed a high selectivity index.

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Bibliographische Detailangaben
Veröffentlicht in:	Biological & pharmaceutical bulletin 1994/08/15, Vol.17(8), pp.1147-1149
Hauptverfasser:	ENDO, Yasuyuki, OHNO, Michihiro, HIRANO, Masaaki, FUJIWARA, Tamio, SATO, Akihiko, HINUMA, Yorio, SHUDO, Koichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - pharmacology Biological and medical sciences chemotherapy Coloring Agents Cytopathogenic Effect, Viral - drug effects HIV-1 - drug effects human immunodeficiency virus (HIV) human immunodeficiency virus 1 Humans Irritants - pharmacology Lyngbya Toxins - pharmacology Medical sciences Pharmacology. Drug treatments teleocidin Tetrazolium Salts Thiazoles Virus Replication - drug effects Viruses - drug effects
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Beschreibung
Zusammenfassung:	Teleocidin B-4 and structurally related synthetic benzolactams were found to be potent inhibitors of cell killing by HIV-1. One of the benzolactams, (-)-BL-V8-310, showed a high selectivity index.
ISSN:	0918-6158 1347-5215
DOI:	10.1248/bpb.17.1147