Recent developments in immunotoxin therapy

Recent developments in immunotoxin therapy

Immunotoxin (IT) research has been ongoing for 15 years. During the past 2 years, work has focused on several areas: on improvements and developments in first- and second-generation ITs; the preparation of new immunotoxin constructs with anti-tumor activity; novel animal models for preclinical evalu...

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Veröffentlicht in:Current opinion in immunology 1994, Vol.6 (5), p.707-714
Hauptverfasser: Ghetie, Maria-Ana, Vitetta, Ellen S.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Disease Models, Animal
Endothelium, Vascular - immunology
Humans
Immunotoxins - chemistry
Immunotoxins - immunology
Immunotoxins - therapeutic use
Mice
Mice, Nude
Mice, SCID
Neoplasms - immunology
Neoplasms - therapy
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Beschreibung
Zusammenfassung:Immunotoxin (IT) research has been ongoing for 15 years. During the past 2 years, work has focused on several areas: on improvements and developments in first- and second-generation ITs; the preparation of new immunotoxin constructs with anti-tumor activity; novel animal models for preclinical evaluation of immunotoxins; and clinical trials, which are now entering Phase II or III in humans.
ISSN:0952-7915
1879-0372
DOI:10.1016/0952-7915(94)90073-6