Application of Langlois' Reagent in Trifluoromethylation Reactions

Application of Langlois' Reagent in Trifluoromethylation Reactions

The incorporation of a trifluoromethyl (CF3) group into organic compounds is of great importance in pharmaceutical, agricultural, and materials science. Trifluoromethylation based on radical intermediates, as a valuable alternative transformation using the inexpensive and stable solid sodium trifluo...

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Veröffentlicht in:Advanced synthesis & catalysis 2014-10, Vol.356 (14-15), p.2895-2906
1. Verfasser: Zhang, Cai
Format: Artikel
Sprache:eng
Schlagworte:
Agronomy
alkenes
Catalysis
Langlois' reagent
Materials science
Organic compounds
radical reactions
Radicals
Sodium
sodium trifluoromethanesulfinate (CF3SO2Na)
Synthesis
Transformations
trifluoromethylation
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Beschreibung
Zusammenfassung:The incorporation of a trifluoromethyl (CF3) group into organic compounds is of great importance in pharmaceutical, agricultural, and materials science. Trifluoromethylation based on radical intermediates, as a valuable alternative transformation using the inexpensive and stable solid sodium trifluoromethanesulfinate (CF3SO2Na; Langlois’ reagent), has attracted much attention and has become a hot research field. This review examines recent advances in radical trifluoromethylation reactions with CF3SO2Na as CF3 source.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201400370