Synthesis of Pyrimidopyrimidinediones in a Deep Eutectic Reaction Mixture

An efficient and general synthesis of hexahydropyrimidopyrimidinediones has been developed employing a low melting L‐(+)‐tartaric acid‐dimethylurea mixture as reaction medium. The melt acts at the same time as solvent, catalyst and reactant. Functionalized hexahydropyrimidopyrimidinediones are obtai...

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Veröffentlicht in:	Advanced synthesis & catalysis 2012-09, Vol.354 (13), p.2368-2372
Hauptverfasser:	Gore, Sangram, Baskaran, Sundarababu, Koenig, Burkhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Catalysts Catalysts: preparations and properties Chemistry eutectic mixtures Eutectic reactions Exact sciences and technology General and physical chemistry glycoluril Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings low melting mixtures Melting Melts Organic chemistry Preparations and properties pyrimidopyrimidinediones Solvents sustainable chemistry Synthesis Tartaric acid Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry
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Beschreibung
Zusammenfassung:	An efficient and general synthesis of hexahydropyrimidopyrimidinediones has been developed employing a low melting L‐(+)‐tartaric acid‐dimethylurea mixture as reaction medium. The melt acts at the same time as solvent, catalyst and reactant. Functionalized hexahydropyrimidopyrimidinediones are obtained in good to excellent yields after simple work‐up.
ISSN:	1615-4150 1615-4169
DOI:	10.1002/adsc.201200257