Designing Multi-Branched Gold Nanoechinus for NIR Light Activated Dual Modal Photodynamic and Photothermal Therapy in the Second Biological Window

Gold nanoechinus can sensitize the formation of singlet oxygen in the first and the second near‐infra red (NIR) biological windows and exert in vivo dual modal photodynamic and photothermal therapeutic effects (PDT and PTT) to destruct the tumors completely. This is the first literature example of t...

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Veröffentlicht in:	Advanced materials (Weinheim) 2014-10, Vol.26 (39), p.6689-6695
Hauptverfasser:	Vijayaraghavan, Priya, Liu, Cheng-Hong, Vankayala, Raviraj, Chiang, Chi-Shiun, Hwang, Kuo Chu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological biological window Biomedical materials Drug Design Gold Gold - chemistry Gold - pharmacology gold nanoechinus In vivo testing In vivo tests Infrared Rays Melanoma, Experimental - drug therapy Mice Nanostructure Nanostructures Photochemotherapy - methods photodynamic therapy Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology photothermal therapy singlet oxygen Therapy Tumors
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Beschreibung
Zusammenfassung:	Gold nanoechinus can sensitize the formation of singlet oxygen in the first and the second near‐infra red (NIR) biological windows and exert in vivo dual modal photodynamic and photothermal therapeutic effects (PDT and PTT) to destruct the tumors completely. This is the first literature example of the destruction of tumors in NIR window II induced by dual modal nanomaterial‐mediated photodynamic and photothermal therapy (NmPDT & NmPTT).
ISSN:	0935-9648 1521-4095
DOI:	10.1002/adma.201400703