Oxidative stress induced by aluminum oxide nanomaterials after acute oral treatment in Wistar rats

ABSTRACT This study investigated the oxidative stress induced after acute oral treatment with 500, 1000 and 2000 mg kg−1 doses of Al2O3‐30 and −40 nm and bulk Al2O3 in Wistar rats. Both the nanomaterials induced significant oxidative stress in a dose‐dependent manner in comparison to the bulk. There...

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Veröffentlicht in:	Journal of applied toxicology 2012-06, Vol.32 (6), p.436-445
Hauptverfasser:	Prabhakar, P. V., Reddy, Utkarsh A., Singh, S. P., Balasubramanyam, A., Rahman, M. F., Indu Kumari, S., Agawane, Sachin B., Murty, U. S. N., Grover, Paramjit, Mahboob, Mohammed
Format:	Artikel
Sprache:	eng
Schlagworte:	acute oral toxicity Administration, Oral Aluminium oxide nanomaterials Aluminum oxide Aluminum Oxide - toxicity Animals antioxidant enzymes Biological and medical sciences Brain - drug effects Brain - metabolism Brain - pathology Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - pathology Chemical and industrial products toxicology. Toxic occupational diseases Female Glutathione - metabolism Heart - drug effects histopathology Kidney - drug effects Kidney - metabolism Kidney - pathology Lesions Lipid Peroxidation - drug effects Liver Liver - drug effects Liver - metabolism Liver - pathology Malondialdehyde - metabolism Medical sciences Metal Nanoparticles - toxicity Metals and various inorganic compounds Myocardium - metabolism Myocardium - pathology Nanomaterials Nanotechnology oxidative stress Oxidative Stress - drug effects Oxidoreductases - metabolism Rats Rats, Wistar Stresses Toxicity Tests, Acute Toxicology Wistar rat
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Zusammenfassung:	ABSTRACT This study investigated the oxidative stress induced after acute oral treatment with 500, 1000 and 2000 mg kg−1 doses of Al2O3‐30 and −40 nm and bulk Al2O3 in Wistar rats. Both the nanomaterials induced significant oxidative stress in a dose‐dependent manner in comparison to the bulk. There was no significant difference between the two nanomaterials. However, the effect decreased with increase with time after treatment. The histopathological examination showed lesions only in liver with Al2O3 nanomaterials at 2000 mg kg−1. Copyright © 2011 John Wiley & Sons, Ltd. This study investigated the oxidative stress induced after acute oral treatment with 500, 1000 and 2000 mg kg−1 doses of Al2O3‐30 and −40 nm and bulk Al2O3 in Wistar rats. Both the nanomaterials induced significant oxidative stress in a dose‐dependent manner in comparison to the bulk. There was no significant difference between the two nanomaterials. However, the effect decreased with increase with time after treatment. The histopathological examination showed lesions only in liver with Al2O3 nanomaterials at 2000 mg kg−1.
ISSN:	0260-437X 1099-1263
DOI:	10.1002/jat.1775