pH-Responsive Theranostic Polymer-Caged Nanobins: Enhanced Cytotoxicity and T sub(1) MRI Contrast by Her2 Targeting

pH-Responsive Theranostic Polymer-Caged Nanobins: Enhanced Cytotoxicity and T sub(1) MRI Contrast by Her2 Targeting

A polymer-caged nanobin (PCN) theranostic platform with a doxorubicin (DXR)-loaded liposomal core and an acid-sensitive polymer shell that is functionalized with herceptin and Gd super(III)-based magnetic resonance imaging (MRI) contrast agents is reported. In vitro testing reveals an 120-fold impro...

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Veröffentlicht in:Particle & particle systems characterization 2013-09, Vol.30 (9), p.770-774
Hauptverfasser: Hong, Bong Jin, Swindell, Elden P, MacRenaris, Keith W, Hankins, Patrick L, Chipre, Anthony J, Mastarone, Daniel J, Ahn, Richard W, Meade, Thomas J, O'Halloran, Thomas V, Nguyen, SonBinh T
Format: Artikel
Sprache:eng
Schlagworte:
Cellular
Contrast agents
Magnetic resonance imaging
Nanostructure
PCN
Platforms
Shells
Uptakes
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Zusammenfassung:A polymer-caged nanobin (PCN) theranostic platform with a doxorubicin (DXR)-loaded liposomal core and an acid-sensitive polymer shell that is functionalized with herceptin and Gd super(III)-based magnetic resonance imaging (MRI) contrast agents is reported. In vitro testing reveals an 120-fold improvement in cellular Gd super(III) uptake in comparison with clinically approved DOTA-Gd super(III), leading to significant T sub(1) MRI contrast enhancement.
ISSN:0934-0866
1521-4117
DOI:10.1002/ppsc.201300158