Stabilization of α-helices by the self-assembly of macrocyclic peptides on the surface of gold nanoparticles for molecular recognition

Stabilization of α-helices by the self-assembly of macrocyclic peptides on the surface of gold nanoparticles for molecular recognition

A novel strategy to stabilize the α-helical secondary structures of peptides upon binding to gold nanoparticles is described. Using a model protein-protein interaction system, we showed that AuNPs decorated with stabilized p53 α-helix peptides can mediate specific molecular recognition with their ta...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2013-08, Vol.49 (69), p.7617-7619
Hauptverfasser: Kim, Boram, Choi, Sung-ju, Han, So-hee, Choi, Kang-Yell, Lim, Yong-beom
Format: Artikel
Sprache:eng
Schlagworte:
Binding
Circular Dichroism
Gold
Gold - chemistry
Macrocyclic compounds
Mathematical models
Metal Nanoparticles - chemistry
Nanoparticles
Peptides
Peptides - chemistry
Peptides - metabolism
Protein Structure, Secondary
Recognition
Self assembly
Strategy
Surface Properties
Tumor Suppressor Protein p53 - chemistry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A novel strategy to stabilize the α-helical secondary structures of peptides upon binding to gold nanoparticles is described. Using a model protein-protein interaction system, we showed that AuNPs decorated with stabilized p53 α-helix peptides can mediate specific molecular recognition with their target protein.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc44644a