A new synthesis of the tripeptide Gly-His-Lys with antimicrobial activity

A new synthesis of the tripeptide Gly-His-Lys with antimicrobial activity

A new solid phase synthesis of the growth-modulating tripeptide Gly-His-Lys is described. 2-Chlorotrityl chloride resin and 9-fluorenylmethoxycarbonyl-(Fmoc), 4-methyltrityl-(Mtt) protecting groups were used. The synthetic tripeptide was tested for its activity against bacteria, yeast and fungi. The...

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Veröffentlicht in:Amino acids 1997-06, Vol.13 (2), p.155-161
Hauptverfasser: Liakopoulou-Kyriakides, M, Pachatouridis, C, Ekateriuiadou, L, Papageorgiou, V P
Format: Artikel
Sprache:eng
Schlagworte:
Amino acids
Antimicrobial agents
Bacteria
Chlorides
Deoxyribonucleic acid
Polymers
Protein synthesis
Solid phase synthesis
Synthesis
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Zusammenfassung:A new solid phase synthesis of the growth-modulating tripeptide Gly-His-Lys is described. 2-Chlorotrityl chloride resin and 9-fluorenylmethoxycarbonyl-(Fmoc), 4-methyltrityl-(Mtt) protecting groups were used. The synthetic tripeptide was tested for its activity against bacteria, yeast and fungi. The in vitro effect of the tripeptide on DNA, RNA and protein synthesis was studied as well.
ISSN:0939-4451
1438-2199
DOI:10.1007/BF01373213