A new strategy to construct a C&z.dbd; C-CF sub(3) subunit viaCuBr-catalyzed domino reaction of homopropargyl amines: an efficient synthesis of trifluoromethyl containing building blocks 4-trifluoromethyl-2,3-dihydro-pyrroliums

A new strategy to construct a C&z.dbd; C-CF sub(3) subunit viaCuBr-catalyzed domino reaction of homopropargyl amines: an efficient synthesis of trifluoromethyl containing building blocks 4-trifluoromethyl-2,3-dihydro-pyrroliums

A new strategy for the construction of a C&z.dbd; C-CF sub(3) subunit has been developed viaCuBr-catalyzed domino cyclization-trifluoromethylation of homopropargyl amines with Umemoto's reagent. 4-Trifluoromethyl-2,3-dihydro-pyrroliums were produced in high yields. The usefulness of these p...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2014-02, Vol.50 (23), p.3048-3051
Hauptverfasser: Ge, Guang-Cun, Huang, Xiao-Jun, Ding, Chang-Hua, Wan, Shi-Li, Dai, Li-Xin, Hou, Xue-Long
Format: Artikel
Sprache:eng
Schlagworte:
Amines
Cascade chemical reactions
Construction
Strategy
Synthesis
Transformations
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Zusammenfassung:A new strategy for the construction of a C&z.dbd; C-CF sub(3) subunit has been developed viaCuBr-catalyzed domino cyclization-trifluoromethylation of homopropargyl amines with Umemoto's reagent. 4-Trifluoromethyl-2,3-dihydro-pyrroliums were produced in high yields. The usefulness of these products has been demonstrated by the transformation of them into various other trifluoromethylated molecules.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc49059a