Signaling networks of Rho GTPases in cell motility
The last decades have witnessed an exponential increase in our knowledge of Rho GTPase signaling network which further highlighted the cross talk between these proteins and the complexity of their signaling pathways. In this review, we summarize the upstream and downstream players from Rho GTPases t...
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| Veröffentlicht in: | Cellular signalling 2013-10, Vol.25 (10), p.1955-1961 |
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| Format: | Artikel |
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| container_end_page | 1961 |
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| container_issue | 10 |
| container_start_page | 1955 |
| container_title | Cellular signalling |
| container_volume | 25 |
| creator | Hanna, Samer El-Sibai, Mirvat |
| description | The last decades have witnessed an exponential increase in our knowledge of Rho GTPase signaling network which further highlighted the cross talk between these proteins and the complexity of their signaling pathways. In this review, we summarize the upstream and downstream players from Rho GTPases that are mainly involved in actin polymerization leading to cell motility and potentially playing a role in cancer cell metastasis.
•We summarize the complexity of Rho GTPase signaling, particularly in cancer cell motility.•We summarize the different upstream regulators in response to various stimuli.•We summarize the main downstream effectors involved in actin polymerization.•We also shed the light on novel findings that challenged previous concepts regarding Rho GTPases. |
| doi_str_mv | 10.1016/j.cellsig.2013.04.009 |
| format | Article |
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•We summarize the complexity of Rho GTPase signaling, particularly in cancer cell motility.•We summarize the different upstream regulators in response to various stimuli.•We summarize the main downstream effectors involved in actin polymerization.•We also shed the light on novel findings that challenged previous concepts regarding Rho GTPases.</description><identifier>ISSN: 0898-6568</identifier><identifier>EISSN: 1873-3913</identifier><identifier>DOI: 10.1016/j.cellsig.2013.04.009</identifier><identifier>PMID: 23669310</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Actin ; Actins - chemistry ; Actins - metabolism ; Cancer ; Cell Movement - genetics ; Cellular ; Cross talk ; Humans ; Motility ; Neoplasms - genetics ; Neoplasms - metabolism ; Neoplasms - pathology ; Networks ; Pathways ; PI3K ; Polymerization ; Proteins ; rho GTP-Binding Proteins - genetics ; rho GTP-Binding Proteins - metabolism ; Rho GTPases ; Signal Transduction - genetics ; Upstream</subject><ispartof>Cellular signalling, 2013-10, Vol.25 (10), p.1955-1961</ispartof><rights>2013 The Authors</rights><rights>Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-e2a2724cbc0c8b6f0eae6e239b2a65332344d3594f9b0dbe64dbd6576f9343c43</citedby><cites>FETCH-LOGICAL-c511t-e2a2724cbc0c8b6f0eae6e239b2a65332344d3594f9b0dbe64dbd6576f9343c43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0898656813001241$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23669310$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hanna, Samer</creatorcontrib><creatorcontrib>El-Sibai, Mirvat</creatorcontrib><title>Signaling networks of Rho GTPases in cell motility</title><title>Cellular signalling</title><addtitle>Cell Signal</addtitle><description>The last decades have witnessed an exponential increase in our knowledge of Rho GTPase signaling network which further highlighted the cross talk between these proteins and the complexity of their signaling pathways. In this review, we summarize the upstream and downstream players from Rho GTPases that are mainly involved in actin polymerization leading to cell motility and potentially playing a role in cancer cell metastasis.
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| fulltext | fulltext |
| identifier | ISSN: 0898-6568 |
| ispartof | Cellular signalling, 2013-10, Vol.25 (10), p.1955-1961 |
| issn | 0898-6568 1873-3913 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Actin Actins - chemistry Actins - metabolism Cancer Cell Movement - genetics Cellular Cross talk Humans Motility Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Networks Pathways PI3K Polymerization Proteins rho GTP-Binding Proteins - genetics rho GTP-Binding Proteins - metabolism Rho GTPases Signal Transduction - genetics Upstream |
| title | Signaling networks of Rho GTPases in cell motility |
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