Clinical MRI for iron detection in Parkinson's disease
Abstract We studied nonheme iron in Parkinson's disease (PD) using clinically available MRI in 36 patients and 21 healthy volunteers. The subjects underwent thorough clinical investigation, including 3-T MRI. Quantitative R 2* was able to reflect symptoms of PD. In addition, the clinically used...
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| Veröffentlicht in: | Clinical imaging 2013-07, Vol.37 (4), p.631-636 |
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| creator | Rossi, Maija Ruottinen, Hanna Soimakallio, Seppo Elovaara, Irina Dastidar, Prasun |
| description | Abstract We studied nonheme iron in Parkinson's disease (PD) using clinically available MRI in 36 patients and 21 healthy volunteers. The subjects underwent thorough clinical investigation, including 3-T MRI. Quantitative R 2* was able to reflect symptoms of PD. In addition, the clinically used susceptibility-weighted imaging differentiated between controls and patients, whereas T2 -weighted imaging did not. Disease-related changes were present not only in substantia nigra but also in globus pallidus. Such changes are associated with neurodegeneration, reflecting the severity of motor impairment. |
| doi_str_mv | 10.1016/j.clinimag.2013.02.001 |
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The subjects underwent thorough clinical investigation, including 3-T MRI. Quantitative R 2* was able to reflect symptoms of PD. In addition, the clinically used susceptibility-weighted imaging differentiated between controls and patients, whereas T2 -weighted imaging did not. Disease-related changes were present not only in substantia nigra but also in globus pallidus. Such changes are associated with neurodegeneration, reflecting the severity of motor impairment.</description><identifier>ISSN: 0899-7071</identifier><identifier>EISSN: 1873-4499</identifier><identifier>DOI: 10.1016/j.clinimag.2013.02.001</identifier><identifier>PMID: 23522789</identifier><identifier>CODEN: CLIMEB</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Age ; Aged ; Aged, 80 and over ; Alzheimer's disease ; Brain Mapping - methods ; Caudate Nucleus - chemistry ; Caudate Nucleus - pathology ; Control equipment ; Corpus Callosum - chemistry ; Corpus Callosum - pathology ; Disease Progression ; Dopamine ; Female ; Globus Pallidus - chemistry ; Globus Pallidus - pathology ; Humans ; Imaging ; Impairment ; Iron ; Iron - analysis ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Methods ; Middle Aged ; Motors ; Parkinson Disease - diagnosis ; Parkinson's disease ; Patients ; Posture ; Radiology ; Substantia Nigra - chemistry ; Substantia Nigra - pathology</subject><ispartof>Clinical imaging, 2013-07, Vol.37 (4), p.631-636</ispartof><rights>Elsevier Inc.</rights><rights>2013 Elsevier Inc.</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c550t-36a37acde9ee326c419ab39d58d2f798a96cec451a45321b15cad0d182fc79753</citedby><cites>FETCH-LOGICAL-c550t-36a37acde9ee326c419ab39d58d2f798a96cec451a45321b15cad0d182fc79753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S089970711300051X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23522789$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rossi, Maija</creatorcontrib><creatorcontrib>Ruottinen, Hanna</creatorcontrib><creatorcontrib>Soimakallio, Seppo</creatorcontrib><creatorcontrib>Elovaara, Irina</creatorcontrib><creatorcontrib>Dastidar, Prasun</creatorcontrib><title>Clinical MRI for iron detection in Parkinson's disease</title><title>Clinical imaging</title><addtitle>Clin Imaging</addtitle><description>Abstract We studied nonheme iron in Parkinson's disease (PD) using clinically available MRI in 36 patients and 21 healthy volunteers. The subjects underwent thorough clinical investigation, including 3-T MRI. Quantitative R 2* was able to reflect symptoms of PD. In addition, the clinically used susceptibility-weighted imaging differentiated between controls and patients, whereas T2 -weighted imaging did not. Disease-related changes were present not only in substantia nigra but also in globus pallidus. Such changes are associated with neurodegeneration, reflecting the severity of motor impairment.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer's disease</subject><subject>Brain Mapping - methods</subject><subject>Caudate Nucleus - chemistry</subject><subject>Caudate Nucleus - pathology</subject><subject>Control equipment</subject><subject>Corpus Callosum - chemistry</subject><subject>Corpus Callosum - pathology</subject><subject>Disease Progression</subject><subject>Dopamine</subject><subject>Female</subject><subject>Globus Pallidus - chemistry</subject><subject>Globus Pallidus - pathology</subject><subject>Humans</subject><subject>Imaging</subject><subject>Impairment</subject><subject>Iron</subject><subject>Iron - analysis</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>Motors</subject><subject>Parkinson Disease - diagnosis</subject><subject>Parkinson's disease</subject><subject>Patients</subject><subject>Posture</subject><subject>Radiology</subject><subject>Substantia Nigra - chemistry</subject><subject>Substantia Nigra - pathology</subject><issn>0899-7071</issn><issn>1873-4499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk1vEzEQhi0EoqHwF6qVOMBlF4-_fUGgiEKlIhAfEjfLsWeR081uaydI_ff1KilIvYSTfXjmtWeeIeQMaAcU1Jt1F4Y0po3_3TEKvKOsoxQekQUYzVshrH1MFtRY22qq4YQ8K2VdAWWFfkpOGJeMaWMXRC3nmOCH5vO3i6afcpPyNDYRtxi2qd7S2Hz1-SqNZRpflSamgr7gc_Kk90PBF4fzlPw8__Bj-am9_PLxYvn-sg1S0m3Llefah4gWkTMVBFi_4jZKE1mvrfFWBQxCgheSM1iBDD7SCIb1QVst-Sl5vc-9ztPNDsvWbVIJOAx-xGlXHCgNwjIpzHFUUqqtlEwfRwXTdajG_McHuLKMcwNz6ssH6Hra5bGOZ08JZUBVSu2pkKdSMvbuOleN-dYBdbNat3b3at2s1lHmqrlaeHaI3602GP-W3buswLs9gFXIn4TZlZBwDBhTrjJdnNLxN94-iAiH9bjCWyz_-nGlFrjv84LN-wWcUirhF78DuUnJFA</recordid><startdate>20130701</startdate><enddate>20130701</enddate><creator>Rossi, Maija</creator><creator>Ruottinen, Hanna</creator><creator>Soimakallio, Seppo</creator><creator>Elovaara, Irina</creator><creator>Dastidar, Prasun</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope><scope>7QO</scope><scope>7SC</scope><scope>7U5</scope><scope>JQ2</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope></search><sort><creationdate>20130701</creationdate><title>Clinical MRI for iron detection in Parkinson's disease</title><author>Rossi, Maija ; Ruottinen, Hanna ; Soimakallio, Seppo ; Elovaara, Irina ; Dastidar, Prasun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c550t-36a37acde9ee326c419ab39d58d2f798a96cec451a45321b15cad0d182fc79753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer's disease</topic><topic>Brain Mapping - methods</topic><topic>Caudate Nucleus - chemistry</topic><topic>Caudate Nucleus - pathology</topic><topic>Control equipment</topic><topic>Corpus Callosum - chemistry</topic><topic>Corpus Callosum - pathology</topic><topic>Disease Progression</topic><topic>Dopamine</topic><topic>Female</topic><topic>Globus Pallidus - chemistry</topic><topic>Globus Pallidus - pathology</topic><topic>Humans</topic><topic>Imaging</topic><topic>Impairment</topic><topic>Iron</topic><topic>Iron - analysis</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Methods</topic><topic>Middle Aged</topic><topic>Motors</topic><topic>Parkinson Disease - diagnosis</topic><topic>Parkinson's disease</topic><topic>Patients</topic><topic>Posture</topic><topic>Radiology</topic><topic>Substantia Nigra - chemistry</topic><topic>Substantia Nigra - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rossi, Maija</creatorcontrib><creatorcontrib>Ruottinen, Hanna</creatorcontrib><creatorcontrib>Soimakallio, Seppo</creatorcontrib><creatorcontrib>Elovaara, Irina</creatorcontrib><creatorcontrib>Dastidar, Prasun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>ProQuest Computer Science Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><jtitle>Clinical imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rossi, Maija</au><au>Ruottinen, Hanna</au><au>Soimakallio, Seppo</au><au>Elovaara, Irina</au><au>Dastidar, Prasun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical MRI for iron detection in Parkinson's disease</atitle><jtitle>Clinical imaging</jtitle><addtitle>Clin Imaging</addtitle><date>2013-07-01</date><risdate>2013</risdate><volume>37</volume><issue>4</issue><spage>631</spage><epage>636</epage><pages>631-636</pages><issn>0899-7071</issn><eissn>1873-4499</eissn><coden>CLIMEB</coden><abstract>Abstract We studied nonheme iron in Parkinson's disease (PD) using clinically available MRI in 36 patients and 21 healthy volunteers. The subjects underwent thorough clinical investigation, including 3-T MRI. Quantitative R 2* was able to reflect symptoms of PD. In addition, the clinically used susceptibility-weighted imaging differentiated between controls and patients, whereas T2 -weighted imaging did not. Disease-related changes were present not only in substantia nigra but also in globus pallidus. Such changes are associated with neurodegeneration, reflecting the severity of motor impairment.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23522789</pmid><doi>10.1016/j.clinimag.2013.02.001</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Age Aged Aged, 80 and over Alzheimer's disease Brain Mapping - methods Caudate Nucleus - chemistry Caudate Nucleus - pathology Control equipment Corpus Callosum - chemistry Corpus Callosum - pathology Disease Progression Dopamine Female Globus Pallidus - chemistry Globus Pallidus - pathology Humans Imaging Impairment Iron Iron - analysis Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Methods Middle Aged Motors Parkinson Disease - diagnosis Parkinson's disease Patients Posture Radiology Substantia Nigra - chemistry Substantia Nigra - pathology |
| title | Clinical MRI for iron detection in Parkinson's disease |
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