Clinical MRI for iron detection in Parkinson's disease

Abstract We studied nonheme iron in Parkinson's disease (PD) using clinically available MRI in 36 patients and 21 healthy volunteers. The subjects underwent thorough clinical investigation, including 3-T MRI. Quantitative R 2* was able to reflect symptoms of PD. In addition, the clinically used...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical imaging 2013-07, Vol.37 (4), p.631-636
Hauptverfasser:	Rossi, Maija, Ruottinen, Hanna, Soimakallio, Seppo, Elovaara, Irina, Dastidar, Prasun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Aged Aged, 80 and over Alzheimer's disease Brain Mapping - methods Caudate Nucleus - chemistry Caudate Nucleus - pathology Control equipment Corpus Callosum - chemistry Corpus Callosum - pathology Disease Progression Dopamine Female Globus Pallidus - chemistry Globus Pallidus - pathology Humans Imaging Impairment Iron Iron - analysis Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Methods Middle Aged Motors Parkinson Disease - diagnosis Parkinson's disease Patients Posture Radiology Substantia Nigra - chemistry Substantia Nigra - pathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Abstract We studied nonheme iron in Parkinson's disease (PD) using clinically available MRI in 36 patients and 21 healthy volunteers. The subjects underwent thorough clinical investigation, including 3-T MRI. Quantitative R 2* was able to reflect symptoms of PD. In addition, the clinically used susceptibility-weighted imaging differentiated between controls and patients, whereas T2 -weighted imaging did not. Disease-related changes were present not only in substantia nigra but also in globus pallidus. Such changes are associated with neurodegeneration, reflecting the severity of motor impairment.
ISSN:	0899-7071 1873-4499
DOI:	10.1016/j.clinimag.2013.02.001