Organic Electrochemical Transistor Array for Recording Transepithelial Ion Transport of Human Airway Epithelial Cells

An organic electrochemical transistor array is integrated with human airway epithelial cells. This integration provides a novel method to couple transepithelial ion transport with electrical current. Activation and inhibition of transepithelial ion transport are readily detected with excellent time...

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Veröffentlicht in:	Advanced materials (Weinheim) 2013-12, Vol.25 (45), p.6575-6580
Hauptverfasser:	Yao, Chunlei, Xie, Changyan, Lin, Peng, Yan, Feng, Huang, Pingbo, Hsing, I-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Arrays cell biosensors Cell Line cystic fibrosis transmembrane conductance regulators Electrochemical Techniques Electrodes Epithelial Cells - cytology Epithelial Cells - metabolism Epithelial Cells - physiology Human Humans ion channels Ion Transport Ions - chemistry Ions - metabolism Organic Chemicals - chemistry organic electrochemical transistors Platforms Polystyrenes - chemistry Recording Semiconductor devices Thiophenes - chemistry transepithelial ion transport Transistors Transistors, Electronic
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Beschreibung
Zusammenfassung:	An organic electrochemical transistor array is integrated with human airway epithelial cells. This integration provides a novel method to couple transepithelial ion transport with electrical current. Activation and inhibition of transepithelial ion transport are readily detected with excellent time resolution. The organic electrochemical transistor array serves as a promising platform for physiological studies and drug testing.
ISSN:	0935-9648 1521-4095
DOI:	10.1002/adma.201302615