N-acetyl-cysteine protects chicken growth plate chondrocytes from T-2 toxin-induced oxidative stress

ABSTRACT T‐2 toxin is now considered to be related to bone malformation such as incomplete ossification, absence of bones and fused bones. In this study, primary cultures of chicken tibial growth plate chondrocytes (GPCs) were treated with various concentrations of T‐2 toxin (5, 50, and 500 n m) in...

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Veröffentlicht in:	Journal of applied toxicology 2012-12, Vol.32 (12), p.980-985
Hauptverfasser:	He, Shao-jun, Hou, Jia-fa, Dai, Yu-yi, Zhou, Zhen-lei, Deng, Yi-feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Alkaline Phosphatase - metabolism Animals antioxidant enzyme Antioxidants Antioxidants - pharmacology Biological and medical sciences Bones Catalase - metabolism Cell Survival - drug effects Cells, Cultured Cellular Cellular biology Chickens Chondrocytes - drug effects Chondrocytes - metabolism Chondrocytes - pathology Dose-Response Relationship, Drug Glutathione - metabolism Growth Plate - drug effects Growth Plate - metabolism Growth Plate - pathology growth plate chondrocyte Homeostasis In vitro testing Malondialdehyde - metabolism Medical sciences N-acetyl-cysteine Oxidative stress Oxidative Stress - drug effects Plant poisons toxicology Poultry Reactive Oxygen Species - metabolism Stresses Superoxide Dismutase - metabolism T-2 toxin T-2 Toxin - toxicity Tibia - drug effects Tibia - metabolism Tibia - pathology Toxicity Toxicology Toxins
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Zusammenfassung:	ABSTRACT T‐2 toxin is now considered to be related to bone malformation such as incomplete ossification, absence of bones and fused bones. In this study, primary cultures of chicken tibial growth plate chondrocytes (GPCs) were treated with various concentrations of T‐2 toxin (5, 50, and 500 n m) in the absence and presence of N‐acetyl‐cysteine (NAC) to investigate the effects of the antioxidant NAC on T‐2 toxin‐induced toxicity. Our results showed that T‐2 toxin markedly decreased cell viability, alkaline phosphatase activity and glutathione content (P
ISSN:	0260-437X 1099-1263
DOI:	10.1002/jat.1697