Effects of Polymer Modification of an Anti-Cancer Drug with Poly(ethylene oxide)

The hydrophobic anti‐cancer drug paclitaxel was modified with the hydrophilic poly(ethylene oxide) to a water‐soluble predrug. The modification of the polymer chain results in a different solution behaviour of the macromolecules compared with the unmodified polymer. The phase diagram of the (quasi)binary system predrug‐water was investigated, and molecular simulations of the predrug were executed in vacuum and in the presence of water. The results are important for further engineering on active drug systems.