Correlation of thrombosis growth rate to pathological wall shear rate during platelet accumulation

Correlation of thrombosis growth rate to pathological wall shear rate during platelet accumulation

Local hemodynamics may strongly influence atherothrombosis, which can lead to acute myocardial infarction and stroke. The relationship between hemodynamics and thrombosis during platelet accumulation was studied through an in vitro flow system consisting of a stenosis. Specifically, wall shear rates...

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Veröffentlicht in:Biotechnology and bioengineering 2012-10, Vol.109 (10), p.2642-2650
Hauptverfasser: Bark Jr, David L., Para, Andrea N., Ku, David N.
Format: Artikel
Sprache:eng
Schlagworte:
accumulation rate
arterial thrombosis
Arteries - pathology
Biotechnology
blood flow
Blood platelets
Blood Platelets - physiology
Cell growth
Constriction, Pathologic - complications
Correlation
Heart attacks
Hemodynamics
Image Processing, Computer-Assisted
In Vitro Techniques
Myocardial infarction
Platelets
shear
Shear rate
shear-induced platelet accumulation
Stress, Mechanical
Stroke
Thrombosis
Thrombosis - pathology
Wall shear rate
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Zusammenfassung:Local hemodynamics may strongly influence atherothrombosis, which can lead to acute myocardial infarction and stroke. The relationship between hemodynamics and thrombosis during platelet accumulation was studied through an in vitro flow system consisting of a stenosis. Specifically, wall shear rates (WSR) ranging from 0 to 100,000 s−1 were ascertained through computations and compared with thrombus growth rates found by image analysis for over 5,000 individual observation points per experiment. A positive correlation (P 6,000 s−1 (P 
ISSN:0006-3592
1097-0290
DOI:10.1002/bit.24537