Silica‐based and organic monolithic capillary columns for LC: Recent trends in proteomics

The use of monolithic liquid chromatography (LC) columns for proteomics, covering the scientific literature from 2004 to the beginning of 2011, is reviewed. Attention is paid to recent developments in column technology and materials, focusing on silica‐based and organic (polystyrene and methacrylate...

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Veröffentlicht in:	Journal of separation science 2011-08, Vol.34 (16), p.1934-1944
Hauptverfasser:	Rozenbrand, Johan, van Bennekom, Wouter P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Capillarity Capillary LC Chromatography, Liquid - instrumentation Chromatography, Liquid - methods Chromatography, Liquid - trends Focusing Humans Liquid chromatography Monolithic capillary columns Polystyrene resins Proteins Proteins - chemistry Proteins - isolation & purification Proteomics Proteomics - instrumentation Proteomics - methods Proteomics - trends Silicon Dioxide - chemistry Tables Trends
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Beschreibung
Zusammenfassung:	The use of monolithic liquid chromatography (LC) columns for proteomics, covering the scientific literature from 2004 to the beginning of 2011, is reviewed. Attention is paid to recent developments in column technology and materials, focusing on silica‐based and organic (polystyrene and methacrylate) monolithic capillary columns for proteomics. The applicability of these columns is illustrated by examples of the analysis of (complex) protein digests and proteins conveniently summarized in tables. Furthermore, characteristics of column materials are compared and future trends and prospects are presented.
ISSN:	1615-9306 1615-9314 1615-9314
DOI:	10.1002/jssc.201100294