Conformation of the tridimensional structure of 1,2,3,4,6-pentagalloyl- Delta b-D-glucopyranose (PGG) by 1H NMR, NOESY and theoretical study and membrane interaction in a simulated phospholipid bilayer: a first insight

1,2,3,4,6-Penta-O-galloyl- Delta *b-D-glucopyranose (PGG) is a polyphenolic compound found in substantial amounts in a number of medicinal herbs. We report (i) its conformational analysis by solution NMR and molecular dynamics calculation and (ii) theoretical study of its interaction with a model me...

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Veröffentlicht in:Magnetic resonance in chemistry 2011-03, Vol.49 (3), p.132-136
Hauptverfasser: Beretta, Giangiacomo, Artali, Roberto, Caneva, Enrico, Facino, Roberto Maffei
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Sprache:eng
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Zusammenfassung:1,2,3,4,6-Penta-O-galloyl- Delta *b-D-glucopyranose (PGG) is a polyphenolic compound found in substantial amounts in a number of medicinal herbs. We report (i) its conformational analysis by solution NMR and molecular dynamics calculation and (ii) theoretical study of its interaction with a model membrane bilayer. The galloyl groups B and E appear to play important roles in the interaction with the phospholipid bilayer.
ISSN:1097-458X
DOI:10.1002/mrc.2718