A Novel One-Pot, Two-Step Synthesis of Polycyclic Indoles via Tandem Intramolecular Hydroamidation/Palladium-Catalyzed Annulation

A Novel One-Pot, Two-Step Synthesis of Polycyclic Indoles via Tandem Intramolecular Hydroamidation/Palladium-Catalyzed Annulation

A robust one‐pot process has been developed for the synthesis of a variety of polycyclic indole skeletons via a consecutive sequence of hydroamidation and palladium‐catalyzed annulation, from inexpensive 2‐chloroanilines bearing tethered acetylenes.

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Bibliographische Detailangaben
Veröffentlicht in:Advanced synthesis & catalysis 2010-10, Vol.352 (14-15), p.2667-2671
Hauptverfasser: Liu, Jianxiu, Zhang, Yongda, Li, Guisheng, Roschangar, Frank, Farina, Vittorio, Senanayake, Chris H., Lu, Bruce Z.
Format: Artikel
Sprache:eng
Schlagworte:
Bearing
Catalysis
chloroanilines
hydroamidation
Indoles
palladium
polycyclic indoles
Synthesis
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Beschreibung
Zusammenfassung:A robust one‐pot process has been developed for the synthesis of a variety of polycyclic indole skeletons via a consecutive sequence of hydroamidation and palladium‐catalyzed annulation, from inexpensive 2‐chloroanilines bearing tethered acetylenes.
ISSN:1615-4150
1615-4169
1615-4169
DOI:10.1002/adsc.201000288