The effect of trombophilia on pregnancy outcome and IVF success

Thrombophilia is a group of inherited and acquired coagulation disorders often associated with an increased risk of thrombosis. Over the last decade, inherited thrombophilia is often referred as a possible cause of recurrent miscarriages and in vitro fertilisation (IVF) failure. However, many studie...

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Veröffentlicht in:Collegium antropologicum 2014-12, Vol.38 (4), p.1153-1161
Hauptverfasser: Goldstajn, Marina Sprem, Kovacević, Daria
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Sprache:eng
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Zusammenfassung:Thrombophilia is a group of inherited and acquired coagulation disorders often associated with an increased risk of thrombosis. Over the last decade, inherited thrombophilia is often referred as a possible cause of recurrent miscarriages and in vitro fertilisation (IVF) failure. However, many studies in this area still give conflicting results, so the goal of our study was to determine the effect of thrombophilia on pregnancy outcome and success of IVF. The study included 38 patients with proven gene mutation for thrombophilia and 53patients without mutations. The studied parameters were age, duration of infertility, dose of gonadotropins, duration of stimulation, number of embryo transfer (ET), number of oocytes retrieved, the number of days to ET and the outcome in terms of delivery (full term or premature), ectopic pregnancy or abortion. There was no significant difference between two groups in the number of procedures performed, the number of twin pregnancies, abortions, twin miscarriages, ectopic pregnancies, births and the etiology of infertility. A statistically significant difference was found in the number of pregnancies (p=0.018) and in duration of infertility which was signifi- cantly longer in the group with thrombophilia (p
ISSN:0350-6134