Astrocytic NDRG2 is involved in glucocorticoid-mediated diabetic mechanical allodynia

Highlights • Activation of SDH astrocytes plays a vital role in diabetic mechanical allodynia. • Glucocorticoids contribute to diabetic tactile allodynia partly via SDH astrocytes. • NDRG2 is involved in glucocorticoid-induced activation of SDH astrocytes. • This work extends glucocorticoid-induced...

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Veröffentlicht in:	Diabetes research and clinical practice 2015-04, Vol.108 (1), p.128-136
Hauptverfasser:	Zuo, Zhong-Fu, Liao, Yong-Hui, Ding, Tan, Dong, Yu-Lin, Qu, Juan, Wang, Jian, Wei, Yan-Yan, Lu, Ya-Cheng, Liu, Xue-Zheng, Li, Yun-Qing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes Astrocytes - drug effects Astrocytes - metabolism Blotting, Western Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - metabolism Diabetic mechanical allodynia Endocrinology & Metabolism Glucocorticoids Glucocorticoids - pharmacology Hyperalgesia - drug therapy Hyperalgesia - etiology Hyperalgesia - metabolism Immunohistochemistry Male NDRG2 Nerve Tissue Proteins - biosynthesis Rats Rats, Sprague-Dawley
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Zusammenfassung:	Highlights • Activation of SDH astrocytes plays a vital role in diabetic mechanical allodynia. • Glucocorticoids contribute to diabetic tactile allodynia partly via SDH astrocytes. • NDRG2 is involved in glucocorticoid-induced activation of SDH astrocytes. • This work extends glucocorticoid-induced diabetic allodynia from neuron to astrocyte.
ISSN:	0168-8227 1872-8227
DOI:	10.1016/j.diabres.2015.01.023