Marker of lipid peroxidation related to diabetic nephropathy in Indonesian type 2 diabetes mellitus patients

Marker of lipid peroxidation related to diabetic nephropathy in Indonesian type 2 diabetes mellitus patients

Highlights • A significant correlation between 8-iso-PGF2α and eGFR in T2DM patients. • Increasing level of MDA was mildly correlated with the decline in eGFR (MDRD). • Increasing UACR inversely correlate with eGFR (corrected-CG, MDRD, and CKD-EPI). • Increased 8-iso-PGF2α and MDA in T2DM patients m...

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Veröffentlicht in:Diabetes research and clinical practice 2015-04, Vol.108 (1), p.193-200
Hauptverfasser: Sauriasari, R, Andrajati, R, Azizahwati, Dharmeizar, Saputri, D.A, Muris, R.U, Manfaatun, A, Amanda, O.F, Setiawan, H, Sakano, N, Wang, D.H, Ogino, K
Format: Artikel
Sprache:eng
Schlagworte:
8-iso-PGF2α
Adult
Aged
Biomarkers - blood
Biomarkers - urine
Creatinine - metabolism
Diabetes Mellitus
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - metabolism
Diabetic Nephropathies - epidemiology
Diabetic Nephropathies - etiology
Diabetic Nephropathies - metabolism
Dinoprost - analogs & derivatives
Dinoprost - blood
Endocrinology & Metabolism
Enzyme-Linked Immunosorbent Assay
Estimated Glomerular Filtration Rate
Female
Glomerular Filtration Rate
Humans
Indonesia - epidemiology
Lipid Peroxidation
Male
Malondialdehyde - metabolism
Middle Aged
Prevalence
Spectrophotometry
Urine Albumin to Creatinine Ratio
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Zusammenfassung:Highlights • A significant correlation between 8-iso-PGF2α and eGFR in T2DM patients. • Increasing level of MDA was mildly correlated with the decline in eGFR (MDRD). • Increasing UACR inversely correlate with eGFR (corrected-CG, MDRD, and CKD-EPI). • Increased 8-iso-PGF2α and MDA in T2DM patients may play a role in the pathophysiologic significance of diabetic nephropathy, in which 8-iso-PGF2α contributes in the initiating process.
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2014.12.016