Effect of pantoprazole on insulin secretion in drug-naïve patients with type 2 diabetes

Highlights • The effect of pantoprazole on insulin secretion in drug-naïve patients with type 2 diabetes was evaluated. • A randomized, double blind, placebo control clinical trial in 14 drug-naïve volunteers was performed. • We found significant increases in late insulin phase and total insulin sec...

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Veröffentlicht in:	Diabetes research and clinical practice 2015-04, Vol.108 (1), p.e11-e13
Hauptverfasser:	González-Ortiz, Manuel, Martínez-Abundis, Esperanza, Mercado-Sesma, Arieh R, Álvarez-Carrillo, Rebeca
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Pyridinylmethylsulfinylbenzimidazoles - administration & dosage Adult Blood Glucose - metabolism Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Dose-Response Relationship, Drug Double-Blind Method Endocrinology & Metabolism Female Humans Insulin - blood Insulin - metabolism Insulin Secretion Male Middle Aged NCT01541735, clinicaltrials.gov Pantoprazole Proton pump inhibitors Proton Pump Inhibitors - administration & dosage Type 2 diabetes
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Zusammenfassung:	Highlights • The effect of pantoprazole on insulin secretion in drug-naïve patients with type 2 diabetes was evaluated. • A randomized, double blind, placebo control clinical trial in 14 drug-naïve volunteers was performed. • We found significant increases in late insulin phase and total insulin secretion. • We found a decrease in HbA1c levels.
ISSN:	0168-8227 1872-8227
DOI:	10.1016/j.diabres.2015.01.039