Impact of carbamylation on three different methods, HPLC, capillary electrophoresis and TINIA of measuring HbA1c levels in patients with kidney disease

Highlights • Comparison of three different measurement methods for HbA1c determination. • Based on nephrology samples, HbA1c measurements could result in different diagnoses. • Carbamylated hemoglobin was assessed based on determination of BUN levels in serum. • Weak influence of carbamylation in al...

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Veröffentlicht in:	Diabetes research and clinical practice 2015-04, Vol.108 (1), p.15-22
Hauptverfasser:	Dolscheid-Pommerich, Ramona C, Kirchner, Sonja, Weigel, Carola, Eichhorn, Lars, Conrad, Rupert, Stoffel-Wagner, Birgit, Zur, Berndt
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Carbamylation Chromatography, High Pressure Liquid - methods Diabetes mellitus Electrophoresis, Capillary - methods Endocrinology & Metabolism Glycated Hemoglobin A - metabolism HbA1c Hemoglobin A - analogs & derivatives Humans Kidney disease Kidney Diseases - blood Middle Aged Nephelometry and Turbidimetry - methods Nephrology
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Zusammenfassung:	Highlights • Comparison of three different measurement methods for HbA1c determination. • Based on nephrology samples, HbA1c measurements could result in different diagnoses. • Carbamylated hemoglobin was assessed based on determination of BUN levels in serum. • Weak influence of carbamylation in all methods.
ISSN:	0168-8227 1872-8227
DOI:	10.1016/j.diabres.2015.01.034