The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration

Highlights • Plasticity of cancer cell migration is the biggest hurdle in the development of anti-metastatic therapeutics. • ROCK and MRCK play critical roles in controlling the plasticity of cancer cell migration. • Inhibition of dual ROCK and MRCK kinases would be a more effective strategy to comb...

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Veröffentlicht in:	Cancer letters 2015-06, Vol.361 (2), p.185-196
Hauptverfasser:	Kale, Vijay Pralhad, Hengst, Jeremy A, Desai, Dhimant H, Amin, Shantu G, Yun, Jong K
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer therapeutics Cancer Cancer therapies Cell adhesion & migration Cell migration plasticity Cell Movement - physiology Cytoskeleton Drugs Genotype & phenotype Hematology, Oncology and Palliative Medicine Humans Kinases Metastasis MRCK Neoplasms - enzymology Neoplasms - genetics Neoplasms - pathology Phosphatase Phosphorylation Polymerization Polypharmacology Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proteins Rho kinase rho-Associated Kinases - genetics rho-Associated Kinases - metabolism ROCK and MRCK inhibitors Signal Transduction
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Zusammenfassung:	Highlights • Plasticity of cancer cell migration is the biggest hurdle in the development of anti-metastatic therapeutics. • ROCK and MRCK play critical roles in controlling the plasticity of cancer cell migration. • Inhibition of dual ROCK and MRCK kinases would be a more effective strategy to combat metastatic cancers.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2015.03.017