Site-Specific Incorporation of the Alkaline Labile, Oxidative Stress Product (5R)-5,6-Dihydro-5-hydroxythymidine in an Oligonucleotide

Site-Specific Incorporation of the Alkaline Labile, Oxidative Stress Product (5R)-5,6-Dihydro-5-hydroxythymidine in an Oligonucleotide

We wish to report the first chemical synthesis of an oligonucleotide containing alkaline labile (5R)-5,6-dihydro-5-hydroxythymidine (1), in which Pd super(0) labile protecting groups are utilized for carrying out the synthesis on a photolabile solid-phase synthesis support.

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Veröffentlicht in:Journal of the American Chemical Society 1994-07, Vol.116 (15), p.6931-6932
Hauptverfasser: Matray, Tracy J, Greenberg, Marc M
Format: Artikel
Sprache:eng
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Zusammenfassung:We wish to report the first chemical synthesis of an oligonucleotide containing alkaline labile (5R)-5,6-dihydro-5-hydroxythymidine (1), in which Pd super(0) labile protecting groups are utilized for carrying out the synthesis on a photolabile solid-phase synthesis support.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja00094a056