Synthesis of anionic peptide nucleic acid oligomers including γ-carboxyethyl thymine monomers

Synthesis of anionic peptide nucleic acid oligomers including γ-carboxyethyl thymine monomers

Synthesis of a modified thymine monomer based on l-Glu, solid phase synthesis of anionic peptide nucleic acid (PNA) oligomers containing the modified monomer and optimization of the deblocking procedure and cleavage conditions of the PNA oligomers from resin are accomplished.

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Veröffentlicht in:Mendeleev communications 2015-01, Vol.25 (1), p.47-48
Hauptverfasser: Dezhenkov, Andrey V., Tankevich, Maria V., Nikolskaya, Elena D., Smirnov, Igor P., Pozmogova, Galina E., Shvets, Vitaly I., Kirillova, Yulia G.
Format: Artikel
Sprache:eng
Schlagworte:
Monomers
Nucleic acids
Oligomers
Peptides
Synthesis
Thymine
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Zusammenfassung:Synthesis of a modified thymine monomer based on l-Glu, solid phase synthesis of anionic peptide nucleic acid (PNA) oligomers containing the modified monomer and optimization of the deblocking procedure and cleavage conditions of the PNA oligomers from resin are accomplished.
ISSN:0959-9436
DOI:10.1016/j.mencom.2015.01.017