Targeted labeling of an early-stage tumor spheroid in a chorioallantoic membrane model with upconversion nanoparticles

In vivo detection of cancer at an early-stage, i.e. smaller than 2 mm, is a challenge in biomedicine. In this work target labeling of an early-stage tumor spheroid (∼500 μm) is realized for the first time in a chick embryo chorioallantoic membrane (CAM) model with monoclonal antibody functionalized...

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Veröffentlicht in:	Nanoscale 2015-02, Vol.7 (5), p.1596-1600
Hauptverfasser:	Liu, Kai, Holz, Jasmin A, Ding, Yadan, Liu, Xiaomin, Zhang, Youlin, Tu, Langping, Kong, Xianggui, Priem, Bram, Nadort, Annemarie, Lambrechts, Saskia A G, Aalders, Maurice C G, Buma, Wybren Jan, Liu, Yichun, Zhang, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - immunology Cell Survival - drug effects Chick Embryo Chickens Chicks Chorioallantoic Membrane - drug effects Chorioallantoic Membrane - physiology Embryos Fluorides - chemistry Humans Marking MCF-7 Cells Membranes Mice Microscopy, Confocal Models, Biological Nanoparticles Nanoparticles - chemistry Nanoparticles - metabolism Nanoparticles - toxicity Neoplasm Staging Neoplasms - pathology Spheroids Tumors Upconversion Yttrium - chemistry
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Zusammenfassung:	In vivo detection of cancer at an early-stage, i.e. smaller than 2 mm, is a challenge in biomedicine. In this work target labeling of an early-stage tumor spheroid (∼500 μm) is realized for the first time in a chick embryo chorioallantoic membrane (CAM) model with monoclonal antibody functionalized upconversion nanoparticles (UCNPs-mAb).
ISSN:	2040-3364 2040-3372
DOI:	10.1039/c4nr05638h