Hemodialysis membrane surface chemistry as a barrier to lipopolysaccharide transfer

Hemodialysis membrane surface chemistry as a barrier to lipopolysaccharide transfer

ABSTRACT During hemodialysis bacterial lipopolysaccharide (LPS) in contaminated dialysate solution may translocate across the hollow fiber membrane (HFM) to a patient's blood, resulting in fever and possible systemic shock. This study investigates LPS transfer across, and adsorption within, nat...

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Veröffentlicht in:Journal of applied polymer science 2015-06, Vol.132 (21), p.np-n/a
Hauptverfasser: Madsen, Ben, Britt, David W., Ho, Chih-Hu, Henrie, Michael, Ford, Cheryl, Stroup, Eric, Maltby, Brent, Olmstead, Doug, Andersen, Marion
Format: Artikel
Sprache:eng
Schlagworte:
applications
Bacteria
biomedical applications
Copolymers
Fever
Fibers
Lumens
Materials science
Membranes
Polymers
Sterilization
Surface chemistry
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Zusammenfassung:ABSTRACT During hemodialysis bacterial lipopolysaccharide (LPS) in contaminated dialysate solution may translocate across the hollow fiber membrane (HFM) to a patient's blood, resulting in fever and possible systemic shock. This study investigates LPS transfer across, and adsorption within, native and modified Fresenius Optiflux® F200NRe polysulfone (PS)/polyvinyl pyrrolidone (PVP) HFMs. Modifications include varied PVP content, addition of a PS‐poly(ethylene glycol) copolymer (PS‐PEG), and bleach sterilization. Under clinically relevant flow conditions LPS from >400 EU mL−1 spiked dialysate is not detected (
ISSN:0021-8995
1097-4628
DOI:10.1002/app.41550