A Fast and Activatable Cross-Linking Strategy for Hydrogel Formation

A Fast and Activatable Cross-Linking Strategy for Hydrogel Formation

Strain‐promoted oxidation‐controlled cyclo­octyne‐1,2‐quinone cycloaddition (SPOCQ) is a fast and activatable cross‐linking strategy for hydrogel formation. Gelation is induced by oxidation, which is performed both chemically using sodium periodate and enzymatically using mushroom tyrosinase. Due to...

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Veröffentlicht in:Advanced materials (Weinheim) 2015-02, Vol.27 (7), p.1235-1240
Hauptverfasser: Jonker, Anika M., Borrmann, Annika, van Eck, Ernst R. H., van Delft, Floris L., Löwik, Dennis W. P. M., van Hest, Jan C. M.
Format: Artikel
Sprache:eng
Schlagworte:
activatable
cross-linking
Crosslinking
Cycloaddition
Formations
hydrogel
Hydrogels
Mushrooms
oxidation
Sodium
Strategy
Tyrosinase
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Zusammenfassung:Strain‐promoted oxidation‐controlled cyclo­octyne‐1,2‐quinone cycloaddition (SPOCQ) is a fast and activatable cross‐linking strategy for hydrogel formation. Gelation is induced by oxidation, which is performed both chemically using sodium periodate and enzymatically using mushroom tyrosinase. Due to the fast reaction kinetics, SPOCQ‐formed hydrogels can be functionalized in one‐pot with an azido‐containing moiety using SPAAC cross‐linking.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201404448