Ruthenium-Catalyzed Heteroatom-Directed Regioselective C–H Arylation of Indoles Using a Removable Tether

Ruthenium-Catalyzed Heteroatom-Directed Regioselective C–H Arylation of Indoles Using a Removable Tether

A new approach to C-2 arylated indoles has been developed by utilizing a ruthenium-catalyzed, heteroatom-directed regioselective C–H arylation. The reaction is highly site-selective and results in very good yields. The highlight of the work is the use of a removable directing group and compatibility...

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Veröffentlicht in:Organic letters 2015-04, Vol.17 (7), p.1766-1769
Hauptverfasser: Tiwari, Virendra Kumar, Kamal, Neha, Kapur, Manmohan
Format: Artikel
Sprache:eng
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Zusammenfassung:A new approach to C-2 arylated indoles has been developed by utilizing a ruthenium-catalyzed, heteroatom-directed regioselective C–H arylation. The reaction is highly site-selective and results in very good yields. The highlight of the work is the use of a removable directing group and compatibility of the catalytic system with halogen functional groups in the substrates.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.5b00535