Human sebum extract induces barrier disruption and cytokine expression in murine epidermis

Highlights • Sebum imparts detrimental effects on skin permeability barrier of hairless mice. • Skin barrier disruption by sebum elicits an epidermal inflammatory cascade. • Sebum-induced dermatitis resembles irritant contact dermatitis.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of dermatological science 2015-04, Vol.78 (1), p.34-43
Hauptverfasser:	Guo, Jiun-Wen, Lin, Tzu-Kai, Wu, Chin-Han, Wei, Kai-Che, Lan, Cheng-Che E, Peng, Amy Chia-Ying, Tsai, Jui-Chen, Sheu, Hamm-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Cytokine expression Cytokines - immunology Cytokines - metabolism Dermatitis Dermatitis, Irritant - immunology Dermatitis, Irritant - metabolism Dermatitis, Irritant - pathology Dermatology Epidermal barrier function Epidermis - immunology Epidermis - metabolism Epidermis - pathology Erythema - immunology Erythema - metabolism Erythema - pathology Human sebum Humans Hyperplasia Inflammation Mediators - immunology Inflammation Mediators - metabolism Male Membrane Fluidity Membrane Lipids - metabolism Mice, Hairless Morphology Parakeratosis - immunology Parakeratosis - metabolism Parakeratosis - pathology Permeability Sebum - immunology Sebum - metabolism Time Factors Water Loss, Insensible
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Beschreibung
Zusammenfassung:	Highlights • Sebum imparts detrimental effects on skin permeability barrier of hairless mice. • Skin barrier disruption by sebum elicits an epidermal inflammatory cascade. • Sebum-induced dermatitis resembles irritant contact dermatitis.
ISSN:	0923-1811 1873-569X
DOI:	10.1016/j.jdermsci.2015.01.010