Early Skin Reaction Following Superficial Proton Irradiation

Balb/c mice were irradiated on the leg in the area of the spread out Bragg peak (SOBP) of a 30 MeV proton beam. The proton beam was modulated to different ranges in order to determine the early skin reaction versus beam quality at different portions of the SOBP. The respective 50% moist desquamation...

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Veröffentlicht in:	JOURNAL OF RADIATION RESEARCH 1991, Vol.32 (2), p.175-180
Hauptverfasser:	Tatsuzaki, H, Arimoto, T, Inada, T, Uwamino, Y, Nakamura, T, Yaguchi, M, Akisada, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dose-Response Relationship, Radiation Energy Transfer Female Mice Mice, Inbred BALB C Protons Radiation Injuries, Experimental - pathology Radiation Tolerance Skin - radiation effects
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Zusammenfassung:	Balb/c mice were irradiated on the leg in the area of the spread out Bragg peak (SOBP) of a 30 MeV proton beam. The proton beam was modulated to different ranges in order to determine the early skin reaction versus beam quality at different portions of the SOBP. The respective 50% moist desquamation doses for 1, 3, and 8. 5 mm penetration were 25. 9, 30. 0, and 30. 4 Gy. Irradiation of the superficial layer with the distal portion of the SOBP produced a significantly more severe reaction than did whole layer irradiation.
ISSN:	0449-3060 1349-9157
DOI:	10.1269/jrr.32.175