New gene targets of PGC-1α and ERRα co-regulation in C2C12 myotubes

As a transcriptional coactivator, PGC-1α contributes to the regulation of a broad range of metabolic processes in skeletal muscle health and disease; however, there is limited information about the genes it transcriptionally regulates. To identify new potential gene targets of PGC-1α regulation, mou...

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Veröffentlicht in:	Molecular biology reports 2014-12, Vol.41 (12), p.8009-8017
Hauptverfasser:	Nsiah-Sefaa, Abena, Brown, Erin L., Russell, Aaron P., Foletta, Victoria C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Anatomy Animal Biochemistry Animals Biomedical and Life Sciences ERRalpha Estrogen-Related Receptor Gene Expression Regulation Histology Humans Life Sciences Mice Microarray Analysis Morphology Muscle Fibers, Skeletal - metabolism Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Receptors, Estrogen - genetics Receptors, Estrogen - metabolism Response Elements Signal Transduction Transcription Factors - genetics Transcription Factors - metabolism Transgenes Up-Regulation
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Zusammenfassung:	As a transcriptional coactivator, PGC-1α contributes to the regulation of a broad range of metabolic processes in skeletal muscle health and disease; however, there is limited information about the genes it transcriptionally regulates. To identify new potential gene targets of PGC-1α regulation, mouse C2C12 myotubes were screened by microarray analysis following PGC-1α overexpression. Genes with an mRNA expression of 2.5-fold or more ( P
ISSN:	0301-4851 1573-4978
DOI:	10.1007/s11033-014-3698-0