Disrupted daily light–dark cycle induces the expression of hepatic gluconeogenic regulatory genes and hyperglycemia with glucose intolerance in mice
► Circadian behavioral rhythm is disrupted under an ultradian light–dark cycle (LD 3:3) in mice. ► Expression of hepatic gluconeogenic regulatory genes is induced under LD 3:3. ► Hepatic and plasma cholesterol levels are increased under LD 3:3. ► Expression of adipose inflammatory genes is unaffecte...
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Veröffentlicht in: | Biochemical and biophysical research communications 2013-03, Vol.432 (1), p.111-115 |
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Sprache: | eng |
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Zusammenfassung: | ► Circadian behavioral rhythm is disrupted under an ultradian light–dark cycle (LD 3:3) in mice. ► Expression of hepatic gluconeogenic regulatory genes is induced under LD 3:3. ► Hepatic and plasma cholesterol levels are increased under LD 3:3. ► Expression of adipose inflammatory genes is unaffected under LD 3:3. ► Hyperglycemia with glucose intolerance is induced under LD 3:3.
We elucidated associations between metabolic disorders and the environmental light–dark (LD) cycle that entrains the circadian clock located in the suprachiasmatic nucleus of mammals. Mice were fed with a high-fat/high-sucrose diet for eight weeks under a normal 12h light–12h dark cycle (LD 12:12) or an ultradian 3h light–3h dark cycle (LD 3:3) that might perturb the central clock. The circadian behavioral rhythms were gradually disturbed under LD 3:3. Hyperglycemia with glucose intolerance and increases in diabetic markers, glycated albumin and hemoglobin A1c, were significantly induced without affecting body weight gain and food consumption in LD 3:3. Expression levels of hepatic gluconeogenic regulatory genes such as Pck1, G6pc, Hnf4a, and Foxo1/3/4 genes were increased under LD 3:3. Hypercholesterolemia with hepatic cholesterol accumulation was also induced in LD 3:3. Ultradian LD 3:3cycles did not affect the adipose inflammation that is considered a major player in obesity-associated metabolic disorders. Our findings provide a link between metabolic disorders and environmental photoperiodic cycles in genetically normal animals. |
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ISSN: | 0006-291X 1090-2104 |
DOI: | 10.1016/j.bbrc.2013.01.076 |