Bridging integrator 1 (BIN1): form, function, and Alzheimer's disease
Highlights • BIN1 is the second most important risk locus for LOAD, after APOE. • BIN1 affects AD risk primarily by modulating tau pathology. • BIN1 is also involved in endocytosis, inflammation, calcium homeostasis, and apoptosis. • BIN1 might present novel opportunities for AD therapy.
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Veröffentlicht in: | Trends in molecular medicine 2013-10, Vol.19 (10), p.594-603 |
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Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | Highlights • BIN1 is the second most important risk locus for LOAD, after APOE. • BIN1 affects AD risk primarily by modulating tau pathology. • BIN1 is also involved in endocytosis, inflammation, calcium homeostasis, and apoptosis. • BIN1 might present novel opportunities for AD therapy. |
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ISSN: | 1471-4914 1471-499X |
DOI: | 10.1016/j.molmed.2013.06.004 |