Bridging integrator 1 (BIN1): form, function, and Alzheimer's disease

Highlights • BIN1 is the second most important risk locus for LOAD, after APOE. • BIN1 affects AD risk primarily by modulating tau pathology. • BIN1 is also involved in endocytosis, inflammation, calcium homeostasis, and apoptosis. • BIN1 might present novel opportunities for AD therapy.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Trends in molecular medicine 2013-10, Vol.19 (10), p.594-603
Hauptverfasser: Tan, Meng-Shan, Yu, Jin-Tai, Tan, Lan
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Highlights • BIN1 is the second most important risk locus for LOAD, after APOE. • BIN1 affects AD risk primarily by modulating tau pathology. • BIN1 is also involved in endocytosis, inflammation, calcium homeostasis, and apoptosis. • BIN1 might present novel opportunities for AD therapy.
ISSN:1471-4914
1471-499X
DOI:10.1016/j.molmed.2013.06.004