Quantitative assessment of the influence of common variation rs16892766 at 8q23.3 with colorectal adenoma and cancer susceptibility
Epidemiological studies indicate a genetic contribution to colorectal cancer (CRC) and colorectal adenoma (CRA) risk, but specific genetic variants remain unknown. Recently, genome-wide association studies have identified 8q23.3-rs16892766 as a new CRC susceptibility locus in populations of European...
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| Veröffentlicht in: | Molecular genetics and genomics : MGG 2015-04, Vol.290 (2), p.461-469 |
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| description | Epidemiological studies indicate a genetic contribution to colorectal cancer (CRC) and colorectal adenoma (CRA) risk, but specific genetic variants remain unknown. Recently, genome-wide association studies have identified 8q23.3-rs16892766 as a new CRC susceptibility locus in populations of European descent. Since then, the relationship between 8q23.3-rs16892766 and CRC/CRA has been reported in various ethnic groups; however, these studies have yielded inconsistent results. To investigate this inconsistency and derive a more precise estimation of the relationship, we conducted a meta-analysis of 13 studies, including 41,728 patients and 44,393 controls for CRC, and 3,767 patients and 11,607 controls for CRA. An overall random-effects per-allele odds ratio of 1.19 (95 % CI: 1.13–1.25,
P
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| doi_str_mv | 10.1007/s00438-014-0928-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1668251670</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3625820011</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-6c3623843c12751cb38537dfdc0a47c073d2c553aabf0c7f1cc9cdd3c589e62e3</originalsourceid><addsrcrecordid>eNqNkU1LHTEUhkOxVKv9Ad2UgJtuRvOdzFKkH4IgQl2H3DOZGplJrklG0W3_eHO5VqQguMohec57cngQ-kzJESVEHxdCBDcdoaIjPTPd4zu0RxXVnVCM7zzXVO6ij6XcEEK1YvoD2mWS9bznYg_9uVxcrKG6Gu48dqX4UmYfK04jrtcehzhOi4_gNxeQ5jlFfOdyaHyrcqHK9EwrhV3F5pbxI47vQ71u6JSyh-om7AYf0-ywiwMG16IyLksBv65hFaZQHw7Q-9FNxX96OvfR1fdvv05_ducXP85OT847EFrWTgFvaxnBgTItKay4kVwP4wDECQ1E84GBlNy51UhAjxSgh2HgIE3vFfN8H33d5q5zul18qXYO7R_T5KJPS7FUKcMkVZq8BRVCSCZ4Qw__Q2_SkmNbZENxQ4SSplF0S0FOpWQ_2nUOs8sPlhK7kWm3Mm2TaTcy7WPr-fKUvKxmPzx3_LPXALYFSnuKv31-MfrV1L8lOqol</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1663804658</pqid></control><display><type>article</type><title>Quantitative assessment of the influence of common variation rs16892766 at 8q23.3 with colorectal adenoma and cancer susceptibility</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Li, Ming ; Gu, Yahong</creator><creatorcontrib>Li, Ming ; Gu, Yahong</creatorcontrib><description>Epidemiological studies indicate a genetic contribution to colorectal cancer (CRC) and colorectal adenoma (CRA) risk, but specific genetic variants remain unknown. Recently, genome-wide association studies have identified 8q23.3-rs16892766 as a new CRC susceptibility locus in populations of European descent. Since then, the relationship between 8q23.3-rs16892766 and CRC/CRA has been reported in various ethnic groups; however, these studies have yielded inconsistent results. To investigate this inconsistency and derive a more precise estimation of the relationship, we conducted a meta-analysis of 13 studies, including 41,728 patients and 44,393 controls for CRC, and 3,767 patients and 11,607 controls for CRA. An overall random-effects per-allele odds ratio of 1.19 (95 % CI: 1.13–1.25,
P
< 10
−5
) was found for the rs16892766 polymorphism and CRC/CRA risk. When stratified by outcome, the rs16892766 polymorphism was significantly associated with increased CRC risk with per-allele OR of 1.22 (95 % CI: 1.18–1.27,
P
< 10
−5
), while no associations were found for CRA (OR = 1.05, 95 % CI: 0.91–1.25,
P
= 0.49). In the subgroup analysis by ethnicity, significantly increased CRC risks were found among Caucasians (OR = 1.23, 95 % CI: 1.17–1.29,
P
< 10
−5
) and African American (OR = 1.18, 95 % CI: 1.07–1.29,
P
= 0.001); while no significant associations were found among other ethnic populations. Similar results were also observed under dominant and recessive genetic models. Ethnicity was identified as a potential source of between-study heterogeneity for rs16892766. When stratified by sample size and study design, significantly increased CRC risks were found for the polymorphism in all genetic models. Our findings demonstrated that rs16892766-C allele might be risk-conferring factors for the development of CRC, but not for CRA.</description><identifier>ISSN: 1617-4615</identifier><identifier>EISSN: 1617-4623</identifier><identifier>DOI: 10.1007/s00438-014-0928-z</identifier><identifier>PMID: 25293934</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adenoma - genetics ; Animal Genetics and Genomics ; Biochemistry ; Biomedical and Life Sciences ; Chromosomes ; Chromosomes, Human, Pair 8 - genetics ; Colorectal cancer ; Colorectal Neoplasms - genetics ; Ethnicity ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genomes ; Genomics ; Human Genetics ; Humans ; Life Sciences ; Microbial Genetics and Genomics ; Minority & ethnic groups ; Original Paper ; Plant Genetics and Genomics ; Polymorphism ; Polymorphism, Single Nucleotide ; Risk ; Tumors</subject><ispartof>Molecular genetics and genomics : MGG, 2015-04, Vol.290 (2), p.461-469</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-6c3623843c12751cb38537dfdc0a47c073d2c553aabf0c7f1cc9cdd3c589e62e3</citedby><cites>FETCH-LOGICAL-c475t-6c3623843c12751cb38537dfdc0a47c073d2c553aabf0c7f1cc9cdd3c589e62e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00438-014-0928-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00438-014-0928-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25293934$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Ming</creatorcontrib><creatorcontrib>Gu, Yahong</creatorcontrib><title>Quantitative assessment of the influence of common variation rs16892766 at 8q23.3 with colorectal adenoma and cancer susceptibility</title><title>Molecular genetics and genomics : MGG</title><addtitle>Mol Genet Genomics</addtitle><addtitle>Mol Genet Genomics</addtitle><description>Epidemiological studies indicate a genetic contribution to colorectal cancer (CRC) and colorectal adenoma (CRA) risk, but specific genetic variants remain unknown. Recently, genome-wide association studies have identified 8q23.3-rs16892766 as a new CRC susceptibility locus in populations of European descent. Since then, the relationship between 8q23.3-rs16892766 and CRC/CRA has been reported in various ethnic groups; however, these studies have yielded inconsistent results. To investigate this inconsistency and derive a more precise estimation of the relationship, we conducted a meta-analysis of 13 studies, including 41,728 patients and 44,393 controls for CRC, and 3,767 patients and 11,607 controls for CRA. An overall random-effects per-allele odds ratio of 1.19 (95 % CI: 1.13–1.25,
P
< 10
−5
) was found for the rs16892766 polymorphism and CRC/CRA risk. When stratified by outcome, the rs16892766 polymorphism was significantly associated with increased CRC risk with per-allele OR of 1.22 (95 % CI: 1.18–1.27,
P
< 10
−5
), while no associations were found for CRA (OR = 1.05, 95 % CI: 0.91–1.25,
P
= 0.49). In the subgroup analysis by ethnicity, significantly increased CRC risks were found among Caucasians (OR = 1.23, 95 % CI: 1.17–1.29,
P
< 10
−5
) and African American (OR = 1.18, 95 % CI: 1.07–1.29,
P
= 0.001); while no significant associations were found among other ethnic populations. Similar results were also observed under dominant and recessive genetic models. Ethnicity was identified as a potential source of between-study heterogeneity for rs16892766. When stratified by sample size and study design, significantly increased CRC risks were found for the polymorphism in all genetic models. Our findings demonstrated that rs16892766-C allele might be risk-conferring factors for the development of CRC, but not for CRA.</description><subject>Adenoma - genetics</subject><subject>Animal Genetics and Genomics</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Chromosomes</subject><subject>Chromosomes, Human, Pair 8 - genetics</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Ethnicity</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Microbial Genetics and Genomics</subject><subject>Minority & ethnic groups</subject><subject>Original Paper</subject><subject>Plant Genetics and Genomics</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Risk</subject><subject>Tumors</subject><issn>1617-4615</issn><issn>1617-4623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkU1LHTEUhkOxVKv9Ad2UgJtuRvOdzFKkH4IgQl2H3DOZGplJrklG0W3_eHO5VqQguMohec57cngQ-kzJESVEHxdCBDcdoaIjPTPd4zu0RxXVnVCM7zzXVO6ij6XcEEK1YvoD2mWS9bznYg_9uVxcrKG6Gu48dqX4UmYfK04jrtcehzhOi4_gNxeQ5jlFfOdyaHyrcqHK9EwrhV3F5pbxI47vQ71u6JSyh-om7AYf0-ywiwMG16IyLksBv65hFaZQHw7Q-9FNxX96OvfR1fdvv05_ducXP85OT847EFrWTgFvaxnBgTItKay4kVwP4wDECQ1E84GBlNy51UhAjxSgh2HgIE3vFfN8H33d5q5zul18qXYO7R_T5KJPS7FUKcMkVZq8BRVCSCZ4Qw__Q2_SkmNbZENxQ4SSplF0S0FOpWQ_2nUOs8sPlhK7kWm3Mm2TaTcy7WPr-fKUvKxmPzx3_LPXALYFSnuKv31-MfrV1L8lOqol</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>Li, Ming</creator><creator>Gu, Yahong</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7SS</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20150401</creationdate><title>Quantitative assessment of the influence of common variation rs16892766 at 8q23.3 with colorectal adenoma and cancer susceptibility</title><author>Li, Ming ; Gu, Yahong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-6c3623843c12751cb38537dfdc0a47c073d2c553aabf0c7f1cc9cdd3c589e62e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adenoma - genetics</topic><topic>Animal Genetics and Genomics</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Chromosomes</topic><topic>Chromosomes, Human, Pair 8 - genetics</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Ethnicity</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Microbial Genetics and Genomics</topic><topic>Minority & ethnic groups</topic><topic>Original Paper</topic><topic>Plant Genetics and Genomics</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Risk</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Ming</creatorcontrib><creatorcontrib>Gu, Yahong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular genetics and genomics : MGG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Ming</au><au>Gu, Yahong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative assessment of the influence of common variation rs16892766 at 8q23.3 with colorectal adenoma and cancer susceptibility</atitle><jtitle>Molecular genetics and genomics : MGG</jtitle><stitle>Mol Genet Genomics</stitle><addtitle>Mol Genet Genomics</addtitle><date>2015-04-01</date><risdate>2015</risdate><volume>290</volume><issue>2</issue><spage>461</spage><epage>469</epage><pages>461-469</pages><issn>1617-4615</issn><eissn>1617-4623</eissn><abstract>Epidemiological studies indicate a genetic contribution to colorectal cancer (CRC) and colorectal adenoma (CRA) risk, but specific genetic variants remain unknown. Recently, genome-wide association studies have identified 8q23.3-rs16892766 as a new CRC susceptibility locus in populations of European descent. Since then, the relationship between 8q23.3-rs16892766 and CRC/CRA has been reported in various ethnic groups; however, these studies have yielded inconsistent results. To investigate this inconsistency and derive a more precise estimation of the relationship, we conducted a meta-analysis of 13 studies, including 41,728 patients and 44,393 controls for CRC, and 3,767 patients and 11,607 controls for CRA. An overall random-effects per-allele odds ratio of 1.19 (95 % CI: 1.13–1.25,
P
< 10
−5
) was found for the rs16892766 polymorphism and CRC/CRA risk. When stratified by outcome, the rs16892766 polymorphism was significantly associated with increased CRC risk with per-allele OR of 1.22 (95 % CI: 1.18–1.27,
P
< 10
−5
), while no associations were found for CRA (OR = 1.05, 95 % CI: 0.91–1.25,
P
= 0.49). In the subgroup analysis by ethnicity, significantly increased CRC risks were found among Caucasians (OR = 1.23, 95 % CI: 1.17–1.29,
P
< 10
−5
) and African American (OR = 1.18, 95 % CI: 1.07–1.29,
P
= 0.001); while no significant associations were found among other ethnic populations. Similar results were also observed under dominant and recessive genetic models. Ethnicity was identified as a potential source of between-study heterogeneity for rs16892766. When stratified by sample size and study design, significantly increased CRC risks were found for the polymorphism in all genetic models. Our findings demonstrated that rs16892766-C allele might be risk-conferring factors for the development of CRC, but not for CRA.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25293934</pmid><doi>10.1007/s00438-014-0928-z</doi><tpages>9</tpages></addata></record> |
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| subjects | Adenoma - genetics Animal Genetics and Genomics Biochemistry Biomedical and Life Sciences Chromosomes Chromosomes, Human, Pair 8 - genetics Colorectal cancer Colorectal Neoplasms - genetics Ethnicity Genetic Association Studies Genetic Predisposition to Disease Genomes Genomics Human Genetics Humans Life Sciences Microbial Genetics and Genomics Minority & ethnic groups Original Paper Plant Genetics and Genomics Polymorphism Polymorphism, Single Nucleotide Risk Tumors |
| title | Quantitative assessment of the influence of common variation rs16892766 at 8q23.3 with colorectal adenoma and cancer susceptibility |
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