Quantitative assessment of the influence of common variation rs16892766 at 8q23.3 with colorectal adenoma and cancer susceptibility

Epidemiological studies indicate a genetic contribution to colorectal cancer (CRC) and colorectal adenoma (CRA) risk, but specific genetic variants remain unknown. Recently, genome-wide association studies have identified 8q23.3-rs16892766 as a new CRC susceptibility locus in populations of European descent. Since then, the relationship between 8q23.3-rs16892766 and CRC/CRA has been reported in various ethnic groups; however, these studies have yielded inconsistent results. To investigate this inconsistency and derive a more precise estimation of the relationship, we conducted a meta-analysis of 13 studies, including 41,728 patients and 44,393 controls for CRC, and 3,767 patients and 11,607 controls for CRA. An overall random-effects per-allele odds ratio of 1.19 (95 % CI: 1.13–1.25, P