The synergistic effect of combination temozolomide and chloroquine treatment is dependent on autophagy formation and p53 status in glioma cells

Highlights • Combination of temozolomide and chloroquine creates a synergistic effect. • The synergistic effect from combination treatment of temozolomide and chloroquine is dependent on autophagy. • The pro-apopototic effect from combination treatment of temozolomide and chloroquine is dependent on...

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Veröffentlicht in:	Cancer letters 2015-05, Vol.360 (2), p.195-204
Hauptverfasser:	Lee, Seung Woo, Kim, Hyun-Kyung, Lee, Na-Hyeon, Yi, Hee-Yeon, Kim, Hong-Sug, Hong, Sung Hee, Hong, Yong-Kil, Joe, Young Ae
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols - pharmacology Apoptosis Apoptosis - drug effects Autophagy Autophagy - drug effects Autophagy - physiology Cancer Cancer therapies Cell cycle Cell growth Cell Growth Processes - drug effects Cell Line, Tumor Chloroquine Chloroquine - administration & dosage Chloroquine - pharmacology Cytotoxicity Dacarbazine - administration & dosage Dacarbazine - analogs & derivatives Dacarbazine - pharmacology Deoxyribonucleic acid DNA Drug dosages Drug Synergism Glioblastoma - drug therapy Glioblastoma - metabolism Glioblastoma - pathology Glioma Hematology, Oncology and Palliative Medicine Humans Kinases p53 Signal transduction Substance abuse treatment Temozolomide Tumor Suppressor Protein p53 - metabolism
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Zusammenfassung:	Highlights • Combination of temozolomide and chloroquine creates a synergistic effect. • The synergistic effect from combination treatment of temozolomide and chloroquine is dependent on autophagy. • The pro-apopototic effect from combination treatment of temozolomide and chloroquine is dependent on p53.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2015.02.012