Psychophysiological correlates of cognitive deficits in family caregivers of patients with Alzheimer Disease

Highlights • Caregivers showed impaired attention, working memory and executive function. • Cortisol/DHEA ratios at 8 AM and 10 PM were higher in caregivers than controls. • BDNF levels were lower in caregivers than non-caregivers. • Cortisol/DHEA ratios were negatively related to cognitive function...

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Veröffentlicht in:	Neuroscience 2015-02, Vol.286, p.371-382
Hauptverfasser:	Corrêa, M.S, Vedovelli, K, Giacobbo, B.L, de Souza, C.E.B, Ferrari, P, de Lima Argimon, I.I, Walz, J.C, Kapczinski, F, Bromberg, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alzheimer Disease BDNF Brain-Derived Neurotrophic Factor - blood caregivers Caregivers - psychology chronic stress Cognition Disorders - etiology Cognition Disorders - metabolism Cognition Disorders - psychology cognitive deficits cortisol Dehydroepiandrosterone - analysis DHEA Female Humans Hydrocortisone - analysis Male Middle Aged Neurology Neuropsychological Tests Stress, Psychological - complications Stress, Psychological - metabolism Stress, Psychological - psychology
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Zusammenfassung:	Highlights • Caregivers showed impaired attention, working memory and executive function. • Cortisol/DHEA ratios at 8 AM and 10 PM were higher in caregivers than controls. • BDNF levels were lower in caregivers than non-caregivers. • Cortisol/DHEA ratios were negatively related to cognitive functions of prefrontal cortex.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.11.052