A role for the outer retina in development of the intrinsic pupillary light reflex in mice

Highlights • We validate a new technique for studying the iPLR in mice. • The iPLR in mice can be elicited by very brief flashes of light. • This is the first report of iPLR development in wild-type mice. • Development of iPLR in mice requires the outer retina and pigmentation. • The strength of iPL...

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Veröffentlicht in:	Neuroscience 2015-02, Vol.286, p.60-78
Hauptverfasser:	Vugler, A, Semo, M, Ortín-Martínez, A, Rojanasakul, A, Nommiste, B, Valiente-Soriano, F.J, García-Ayuso, D, Coffey, P, Vidal-Sanz, M, Gias, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - physiology Animals Atropine - pharmacology Dark Adaptation development Gene Knock-In Techniques melanopsin Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Muscarinic Antagonists - pharmacology Neurology Photic Stimulation pigmentation pupillary light reflex rd mice Reflex, Pupillary - drug effects Retina - metabolism Retina - physiology Retinal Cone Photoreceptor Cells - physiology Retinal Rod Photoreceptor Cells - physiology retinitis pigmentosa Rod Opsins - genetics Rod Opsins - metabolism Rod Opsins - physiology
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Zusammenfassung:	Highlights • We validate a new technique for studying the iPLR in mice. • The iPLR in mice can be elicited by very brief flashes of light. • This is the first report of iPLR development in wild-type mice. • Development of iPLR in mice requires the outer retina and pigmentation. • The strength of iPLR increases with age in retinal degeneration despite ipRGC loss.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.11.044