$CD47 Agonist Peptides Induce Programmed Cell Death in Refractory Chronic Lymphocytic Leukemia B Cells via PLC gamma 1 Activation: Evidence from Mice and Humans$

CD47 Agonist Peptides Induce Programmed Cell Death in Refractory Chronic Lymphocytic Leukemia B Cells via PLC gamma 1 Activation: Evidence from Mice and Humans

In this study, Santos Susin and colleagues demonstrate that a serum-stable CD47 agonist peptide is highly effective at inducing apoptosis in chronic lymphocytic leukemia B-cells and mice.

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Bibliographische Detailangaben
Veröffentlicht in:	PLoS medicine 2015-03, Vol.12 (3)
Hauptverfasser:	Martinez-Torres, Ana-Carolina, Quiney, Claire, Attout, Tarik, Boullet, Heloise, Herbi, Linda, Vela, Laura, Barbier, Sandrine, Chateau, Danielle, Chapiro, Elise, Nguyen-Khac, Florence, Davi, Frederic, Le Garff-Tavernier, Magali, Moumne, Roba, Sarfati, Marika, Karoyan, Philippe, Merle-Beral, Helene, Launay, Pierre, Susin, Santos A
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	In this study, Santos Susin and colleagues demonstrate that a serum-stable CD47 agonist peptide is highly effective at inducing apoptosis in chronic lymphocytic leukemia B-cells and mice.
ISSN:	1549-1277 1549-1676
DOI:	10.1371/journal.pmed.1001796