Simvastatin exhibits antiproliferative effects on spheres derived from canine mammary carcinoma cells

Mammary cancer is the most frequent type of tumor in the female canine. Treatments are mainly limited to surgery and chemotherapy; however, these tumors may develop clinical recurrence, metastasis and chemoresistance. The existence of a subpopulation of cancer cells with stemness features called can...

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Veröffentlicht in:	Oncology reports 2015-05, Vol.33 (5), p.2235-2244
Hauptverfasser:	TORRES, CRISTIAN G, OLIVARES, ARACELI, STOORE, CAROLL
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Apoptosis Blotting, Western Breast cancer Cancer therapies canine mammary cancer CD24 CD44 Cell cycle Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects CF41.Mg cells Chemotherapy Cholesterol Cloning Deoxyribonucleic acid DNA Dog Diseases - pathology Dogs Drug resistance Drug therapy Experiments Female Flow Cytometry Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Immunoglobulins Immunohistochemistry In Situ Nick-End Labeling In Vitro Techniques Mammary Neoplasms, Animal - pathology Metastasis Neoplastic Stem Cells - drug effects Patient outcomes Proteins Simvastatin Simvastatin - pharmacology Spheres Spheroids, Cellular - drug effects Stem cells Studies Tumors Veterinary medicine
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