Feasibility of pre-operative chemoradiotherapy with gemcitabine to treat pancreatic cancer in patients with impaired renal function
Although pre-operative chemoradiotherapy appears to be a promising treatment for patients with pancreatic ductal adenocarcinoma, there have been no reports of the feasibility of pre-operative chemoradiotherapy in pancreatic ductal adenocarcinoma patients with renal impairment. The aim of this study...
Gespeichert in:
| Veröffentlicht in: | Japanese journal of clinical oncology 2015-04, Vol.45 (4), p.343-348 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 348 |
|---|---|
| container_issue | 4 |
| container_start_page | 343 |
| container_title | Japanese journal of clinical oncology |
| container_volume | 45 |
| creator | Tomimaru, Yoshito Eguchi, Hidetoshi Satoh, Taroh Tomokuni, Akira Asaoka, Tadafumi Wada, Hiroshi Marubashi, Shigeru Ogawa, Kazuhiko Takehara, Tetsuo Mori, Masaki Doki, Yuichiro Nagano, Hiroaki |
| description | Although pre-operative chemoradiotherapy appears to be a promising treatment for patients with pancreatic ductal adenocarcinoma, there have been no reports of the feasibility of pre-operative chemoradiotherapy in pancreatic ductal adenocarcinoma patients with renal impairment. The aim of this study was to evaluate retrospectively the feasibility of pre-operative chemoradiotherapy in pancreatic ductal adenocarcinoma patients with renal impairment.
Twelve patients with resectable pancreatic ductal adenocarcinoma and a creatinine clearance of |
| doi_str_mv | 10.1093/jjco/hyu224 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1667966289</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1667966289</sourcerecordid><originalsourceid>FETCH-LOGICAL-c350t-68909dbabd8ad6552d759e219105eb4d3257e4b7f77009472f8d5daad0a3e6a13</originalsourceid><addsrcrecordid>eNo9kEtLxDAUhYMoOj5W7iVLQapJ2qTNUsQXDLjRdblNbp0MbVOTVJm1f9wOo67u4fDds_gIOefsmjOd36zXxt-sNpMQxR5Z8ELJLFeC75MFy1WViYrzI3Ic45oxJquiPCRHQspKF7JYkO8HhOga17m0ob6lY8DMjxgguU-kZoW9D2CdT6u5Gzf0y6UVfcfeuASNG5AmT1NASHSEwWyDM9TMEQN1w1wmh0OKuz_Xj-ACWhpwgI6202CS88MpOWihi3j2e0_I28P9691Ttnx5fL67XWYmlyxlqtJM2wYaW4FVUgpbSo2Ca84kNoXNhSyxaMq2LBnTRSnaykoLYBnkqIDnJ-RytzsG_zFhTHXvosGugwH9FGuuVKmVEpWe0asdaoKPMWBbj8H1EDY1Z_XWer21Xu-sz_TF7_DU9Gj_2T_N-Q_4wIJ_</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1667966289</pqid></control><display><type>article</type><title>Feasibility of pre-operative chemoradiotherapy with gemcitabine to treat pancreatic cancer in patients with impaired renal function</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Tomimaru, Yoshito ; Eguchi, Hidetoshi ; Satoh, Taroh ; Tomokuni, Akira ; Asaoka, Tadafumi ; Wada, Hiroshi ; Marubashi, Shigeru ; Ogawa, Kazuhiko ; Takehara, Tetsuo ; Mori, Masaki ; Doki, Yuichiro ; Nagano, Hiroaki</creator><creatorcontrib>Tomimaru, Yoshito ; Eguchi, Hidetoshi ; Satoh, Taroh ; Tomokuni, Akira ; Asaoka, Tadafumi ; Wada, Hiroshi ; Marubashi, Shigeru ; Ogawa, Kazuhiko ; Takehara, Tetsuo ; Mori, Masaki ; Doki, Yuichiro ; Nagano, Hiroaki</creatorcontrib><description>Although pre-operative chemoradiotherapy appears to be a promising treatment for patients with pancreatic ductal adenocarcinoma, there have been no reports of the feasibility of pre-operative chemoradiotherapy in pancreatic ductal adenocarcinoma patients with renal impairment. The aim of this study was to evaluate retrospectively the feasibility of pre-operative chemoradiotherapy in pancreatic ductal adenocarcinoma patients with renal impairment.
Twelve patients with resectable pancreatic ductal adenocarcinoma and a creatinine clearance of <60 ml/min were enrolled in this study. Gemcitabine-based pre-operative chemoradiotherapy was performed, followed by surgery. The feasibility of the treatment was evaluated in terms of clinical outcome and adverse events in the patients.
All 12 patients completed gemcitabine-based pre-operative chemoradiotherapy without worsening of renal function. Restaging after the therapy revealed radiologically unresectable disease in two patients. Among the remaining 10 patients who underwent laparotomy, curative resection was performed in eight patients. After curative resection, five patients out of the eight completed post-operative adjuvant therapy. The 1- and 3-year survival rates after the start of chemoradiotherapy in the 12 patients were 80.8 and 36.9%, respectively.
Our findings suggest that gemcitabine-based pre-operative chemoradiotherapy may be a safe and effective treatment for pancreatic ductal adenocarcinoma in patients with renal impairment.</description><identifier>ISSN: 0368-2811</identifier><identifier>EISSN: 1465-3621</identifier><identifier>DOI: 10.1093/jjco/hyu224</identifier><identifier>PMID: 25589454</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antimetabolites, Antineoplastic - therapeutic use ; Carcinoma, Pancreatic Ductal - mortality ; Carcinoma, Pancreatic Ductal - pathology ; Carcinoma, Pancreatic Ductal - therapy ; Chemoradiotherapy - methods ; Deoxycytidine - analogs & derivatives ; Deoxycytidine - therapeutic use ; Feasibility Studies ; Female ; Humans ; Male ; Middle Aged ; Pancreatic Neoplasms - mortality ; Pancreatic Neoplasms - pathology ; Pancreatic Neoplasms - therapy ; Preoperative Care ; Renal Insufficiency ; Retrospective Studies ; Survival Rate ; Treatment Outcome</subject><ispartof>Japanese journal of clinical oncology, 2015-04, Vol.45 (4), p.343-348</ispartof><rights>The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c350t-68909dbabd8ad6552d759e219105eb4d3257e4b7f77009472f8d5daad0a3e6a13</citedby><cites>FETCH-LOGICAL-c350t-68909dbabd8ad6552d759e219105eb4d3257e4b7f77009472f8d5daad0a3e6a13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25589454$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tomimaru, Yoshito</creatorcontrib><creatorcontrib>Eguchi, Hidetoshi</creatorcontrib><creatorcontrib>Satoh, Taroh</creatorcontrib><creatorcontrib>Tomokuni, Akira</creatorcontrib><creatorcontrib>Asaoka, Tadafumi</creatorcontrib><creatorcontrib>Wada, Hiroshi</creatorcontrib><creatorcontrib>Marubashi, Shigeru</creatorcontrib><creatorcontrib>Ogawa, Kazuhiko</creatorcontrib><creatorcontrib>Takehara, Tetsuo</creatorcontrib><creatorcontrib>Mori, Masaki</creatorcontrib><creatorcontrib>Doki, Yuichiro</creatorcontrib><creatorcontrib>Nagano, Hiroaki</creatorcontrib><title>Feasibility of pre-operative chemoradiotherapy with gemcitabine to treat pancreatic cancer in patients with impaired renal function</title><title>Japanese journal of clinical oncology</title><addtitle>Jpn J Clin Oncol</addtitle><description>Although pre-operative chemoradiotherapy appears to be a promising treatment for patients with pancreatic ductal adenocarcinoma, there have been no reports of the feasibility of pre-operative chemoradiotherapy in pancreatic ductal adenocarcinoma patients with renal impairment. The aim of this study was to evaluate retrospectively the feasibility of pre-operative chemoradiotherapy in pancreatic ductal adenocarcinoma patients with renal impairment.
Twelve patients with resectable pancreatic ductal adenocarcinoma and a creatinine clearance of <60 ml/min were enrolled in this study. Gemcitabine-based pre-operative chemoradiotherapy was performed, followed by surgery. The feasibility of the treatment was evaluated in terms of clinical outcome and adverse events in the patients.
All 12 patients completed gemcitabine-based pre-operative chemoradiotherapy without worsening of renal function. Restaging after the therapy revealed radiologically unresectable disease in two patients. Among the remaining 10 patients who underwent laparotomy, curative resection was performed in eight patients. After curative resection, five patients out of the eight completed post-operative adjuvant therapy. The 1- and 3-year survival rates after the start of chemoradiotherapy in the 12 patients were 80.8 and 36.9%, respectively.
Our findings suggest that gemcitabine-based pre-operative chemoradiotherapy may be a safe and effective treatment for pancreatic ductal adenocarcinoma in patients with renal impairment.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antimetabolites, Antineoplastic - therapeutic use</subject><subject>Carcinoma, Pancreatic Ductal - mortality</subject><subject>Carcinoma, Pancreatic Ductal - pathology</subject><subject>Carcinoma, Pancreatic Ductal - therapy</subject><subject>Chemoradiotherapy - methods</subject><subject>Deoxycytidine - analogs & derivatives</subject><subject>Deoxycytidine - therapeutic use</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pancreatic Neoplasms - mortality</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Pancreatic Neoplasms - therapy</subject><subject>Preoperative Care</subject><subject>Renal Insufficiency</subject><subject>Retrospective Studies</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><issn>0368-2811</issn><issn>1465-3621</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLxDAUhYMoOj5W7iVLQapJ2qTNUsQXDLjRdblNbp0MbVOTVJm1f9wOo67u4fDds_gIOefsmjOd36zXxt-sNpMQxR5Z8ELJLFeC75MFy1WViYrzI3Ic45oxJquiPCRHQspKF7JYkO8HhOga17m0ob6lY8DMjxgguU-kZoW9D2CdT6u5Gzf0y6UVfcfeuASNG5AmT1NASHSEwWyDM9TMEQN1w1wmh0OKuz_Xj-ACWhpwgI6202CS88MpOWihi3j2e0_I28P9691Ttnx5fL67XWYmlyxlqtJM2wYaW4FVUgpbSo2Ca84kNoXNhSyxaMq2LBnTRSnaykoLYBnkqIDnJ-RytzsG_zFhTHXvosGugwH9FGuuVKmVEpWe0asdaoKPMWBbj8H1EDY1Z_XWer21Xu-sz_TF7_DU9Gj_2T_N-Q_4wIJ_</recordid><startdate>201504</startdate><enddate>201504</enddate><creator>Tomimaru, Yoshito</creator><creator>Eguchi, Hidetoshi</creator><creator>Satoh, Taroh</creator><creator>Tomokuni, Akira</creator><creator>Asaoka, Tadafumi</creator><creator>Wada, Hiroshi</creator><creator>Marubashi, Shigeru</creator><creator>Ogawa, Kazuhiko</creator><creator>Takehara, Tetsuo</creator><creator>Mori, Masaki</creator><creator>Doki, Yuichiro</creator><creator>Nagano, Hiroaki</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201504</creationdate><title>Feasibility of pre-operative chemoradiotherapy with gemcitabine to treat pancreatic cancer in patients with impaired renal function</title><author>Tomimaru, Yoshito ; Eguchi, Hidetoshi ; Satoh, Taroh ; Tomokuni, Akira ; Asaoka, Tadafumi ; Wada, Hiroshi ; Marubashi, Shigeru ; Ogawa, Kazuhiko ; Takehara, Tetsuo ; Mori, Masaki ; Doki, Yuichiro ; Nagano, Hiroaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c350t-68909dbabd8ad6552d759e219105eb4d3257e4b7f77009472f8d5daad0a3e6a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antimetabolites, Antineoplastic - therapeutic use</topic><topic>Carcinoma, Pancreatic Ductal - mortality</topic><topic>Carcinoma, Pancreatic Ductal - pathology</topic><topic>Carcinoma, Pancreatic Ductal - therapy</topic><topic>Chemoradiotherapy - methods</topic><topic>Deoxycytidine - analogs & derivatives</topic><topic>Deoxycytidine - therapeutic use</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pancreatic Neoplasms - mortality</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Pancreatic Neoplasms - therapy</topic><topic>Preoperative Care</topic><topic>Renal Insufficiency</topic><topic>Retrospective Studies</topic><topic>Survival Rate</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tomimaru, Yoshito</creatorcontrib><creatorcontrib>Eguchi, Hidetoshi</creatorcontrib><creatorcontrib>Satoh, Taroh</creatorcontrib><creatorcontrib>Tomokuni, Akira</creatorcontrib><creatorcontrib>Asaoka, Tadafumi</creatorcontrib><creatorcontrib>Wada, Hiroshi</creatorcontrib><creatorcontrib>Marubashi, Shigeru</creatorcontrib><creatorcontrib>Ogawa, Kazuhiko</creatorcontrib><creatorcontrib>Takehara, Tetsuo</creatorcontrib><creatorcontrib>Mori, Masaki</creatorcontrib><creatorcontrib>Doki, Yuichiro</creatorcontrib><creatorcontrib>Nagano, Hiroaki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tomimaru, Yoshito</au><au>Eguchi, Hidetoshi</au><au>Satoh, Taroh</au><au>Tomokuni, Akira</au><au>Asaoka, Tadafumi</au><au>Wada, Hiroshi</au><au>Marubashi, Shigeru</au><au>Ogawa, Kazuhiko</au><au>Takehara, Tetsuo</au><au>Mori, Masaki</au><au>Doki, Yuichiro</au><au>Nagano, Hiroaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Feasibility of pre-operative chemoradiotherapy with gemcitabine to treat pancreatic cancer in patients with impaired renal function</atitle><jtitle>Japanese journal of clinical oncology</jtitle><addtitle>Jpn J Clin Oncol</addtitle><date>2015-04</date><risdate>2015</risdate><volume>45</volume><issue>4</issue><spage>343</spage><epage>348</epage><pages>343-348</pages><issn>0368-2811</issn><eissn>1465-3621</eissn><abstract>Although pre-operative chemoradiotherapy appears to be a promising treatment for patients with pancreatic ductal adenocarcinoma, there have been no reports of the feasibility of pre-operative chemoradiotherapy in pancreatic ductal adenocarcinoma patients with renal impairment. The aim of this study was to evaluate retrospectively the feasibility of pre-operative chemoradiotherapy in pancreatic ductal adenocarcinoma patients with renal impairment.
Twelve patients with resectable pancreatic ductal adenocarcinoma and a creatinine clearance of <60 ml/min were enrolled in this study. Gemcitabine-based pre-operative chemoradiotherapy was performed, followed by surgery. The feasibility of the treatment was evaluated in terms of clinical outcome and adverse events in the patients.
All 12 patients completed gemcitabine-based pre-operative chemoradiotherapy without worsening of renal function. Restaging after the therapy revealed radiologically unresectable disease in two patients. Among the remaining 10 patients who underwent laparotomy, curative resection was performed in eight patients. After curative resection, five patients out of the eight completed post-operative adjuvant therapy. The 1- and 3-year survival rates after the start of chemoradiotherapy in the 12 patients were 80.8 and 36.9%, respectively.
Our findings suggest that gemcitabine-based pre-operative chemoradiotherapy may be a safe and effective treatment for pancreatic ductal adenocarcinoma in patients with renal impairment.</abstract><cop>England</cop><pmid>25589454</pmid><doi>10.1093/jjco/hyu224</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0368-2811 |
| ispartof | Japanese journal of clinical oncology, 2015-04, Vol.45 (4), p.343-348 |
| issn | 0368-2811 1465-3621 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1667966289 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Aged Aged, 80 and over Antimetabolites, Antineoplastic - therapeutic use Carcinoma, Pancreatic Ductal - mortality Carcinoma, Pancreatic Ductal - pathology Carcinoma, Pancreatic Ductal - therapy Chemoradiotherapy - methods Deoxycytidine - analogs & derivatives Deoxycytidine - therapeutic use Feasibility Studies Female Humans Male Middle Aged Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Pancreatic Neoplasms - therapy Preoperative Care Renal Insufficiency Retrospective Studies Survival Rate Treatment Outcome |
| title | Feasibility of pre-operative chemoradiotherapy with gemcitabine to treat pancreatic cancer in patients with impaired renal function |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-30T22%3A42%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Feasibility%20of%20pre-operative%20chemoradiotherapy%20with%20gemcitabine%20to%20treat%20pancreatic%20cancer%20in%20patients%20with%20impaired%20renal%20function&rft.jtitle=Japanese%20journal%20of%20clinical%20oncology&rft.au=Tomimaru,%20Yoshito&rft.date=2015-04&rft.volume=45&rft.issue=4&rft.spage=343&rft.epage=348&rft.pages=343-348&rft.issn=0368-2811&rft.eissn=1465-3621&rft_id=info:doi/10.1093/jjco/hyu224&rft_dat=%3Cproquest_cross%3E1667966289%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1667966289&rft_id=info:pmid/25589454&rfr_iscdi=true |