Feasibility of pre-operative chemoradiotherapy with gemcitabine to treat pancreatic cancer in patients with impaired renal function

Although pre-operative chemoradiotherapy appears to be a promising treatment for patients with pancreatic ductal adenocarcinoma, there have been no reports of the feasibility of pre-operative chemoradiotherapy in pancreatic ductal adenocarcinoma patients with renal impairment. The aim of this study...

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Veröffentlicht in:	Japanese journal of clinical oncology 2015-04, Vol.45 (4), p.343-348
Hauptverfasser:	Tomimaru, Yoshito, Eguchi, Hidetoshi, Satoh, Taroh, Tomokuni, Akira, Asaoka, Tadafumi, Wada, Hiroshi, Marubashi, Shigeru, Ogawa, Kazuhiko, Takehara, Tetsuo, Mori, Masaki, Doki, Yuichiro, Nagano, Hiroaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antimetabolites, Antineoplastic - therapeutic use Carcinoma, Pancreatic Ductal - mortality Carcinoma, Pancreatic Ductal - pathology Carcinoma, Pancreatic Ductal - therapy Chemoradiotherapy - methods Deoxycytidine - analogs & derivatives Deoxycytidine - therapeutic use Feasibility Studies Female Humans Male Middle Aged Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Pancreatic Neoplasms - therapy Preoperative Care Renal Insufficiency Retrospective Studies Survival Rate Treatment Outcome
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Zusammenfassung:	Although pre-operative chemoradiotherapy appears to be a promising treatment for patients with pancreatic ductal adenocarcinoma, there have been no reports of the feasibility of pre-operative chemoradiotherapy in pancreatic ductal adenocarcinoma patients with renal impairment. The aim of this study was to evaluate retrospectively the feasibility of pre-operative chemoradiotherapy in pancreatic ductal adenocarcinoma patients with renal impairment. Twelve patients with resectable pancreatic ductal adenocarcinoma and a creatinine clearance of
ISSN:	0368-2811 1465-3621
DOI:	10.1093/jjco/hyu224