Interactive effects of oligofructose and obesity predisposition on gut hormones and microbiota in diet‐induced obese rats
Objective Oligofructose (OFS) is a prebiotic that reduces energy intake and fat mass via changes in gut satiety hormones and microbiota. The effects of OFS may vary depending on predisposition to obesity. The aim of this study was to examine the effect of OFS in diet‐induced obese (DIO) and diet‐res...
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| Veröffentlicht in: | Obesity (Silver Spring, Md.) Md.), 2015-04, Vol.23 (4), p.769-778 |
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| creator | Cluny, Nina L. Eller, Lindsay K. Keenan, Catherine M. Reimer, Raylene A. Sharkey, Keith A. |
| description | Objective
Oligofructose (OFS) is a prebiotic that reduces energy intake and fat mass via changes in gut satiety hormones and microbiota. The effects of OFS may vary depending on predisposition to obesity. The aim of this study was to examine the effect of OFS in diet‐induced obese (DIO) and diet‐resistant (DR) rats.
Methods
Adult, male DIO, and DR rats were randomized to: high‐fat/high‐sucrose (HFS) diet or HFS diet + 10% OFS for 6 weeks. Body composition, food intake, gut microbiota, plasma gut hormones, and cannabinoid CB1 receptor expression in the nodose ganglia were measured.
Results
OFS reduced body weight, energy intake, and fat mass in both phenotypes (P |
| doi_str_mv | 10.1002/oby.21017 |
| format | Article |
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Oligofructose (OFS) is a prebiotic that reduces energy intake and fat mass via changes in gut satiety hormones and microbiota. The effects of OFS may vary depending on predisposition to obesity. The aim of this study was to examine the effect of OFS in diet‐induced obese (DIO) and diet‐resistant (DR) rats.
Methods
Adult, male DIO, and DR rats were randomized to: high‐fat/high‐sucrose (HFS) diet or HFS diet + 10% OFS for 6 weeks. Body composition, food intake, gut microbiota, plasma gut hormones, and cannabinoid CB1 receptor expression in the nodose ganglia were measured.
Results
OFS reduced body weight, energy intake, and fat mass in both phenotypes (P < 0.05). Select gut microbiota differed in DIO versus DR rats (P < 0.05), the differences being eliminated by OFS. OFS did not modify plasma ghrelin or CB1 expression in nodose ganglia, but plasma levels of GIP were reduced and PYY were elevated (P < 0.05) by OFS.
Conclusions
OFS was able to reduce body weight and adiposity in both prone and resistant obese phenotypes. OFS‐induced changes in gut microbiota profiles in DIO and DR rats, along with changes in gut hormone levels, likely contribute to the sustained lower body weights.</description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1002/oby.21017</identifier><identifier>PMID: 25820256</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adiposity - drug effects ; Animals ; Body Composition - drug effects ; Body Weight - drug effects ; Diet ; Dietary Fats - administration & dosage ; Eating - drug effects ; Gastrointestinal Hormones - metabolism ; Ghrelin ; Glucagon-Like Peptide 1 - metabolism ; Hormones ; Male ; Microbiota ; Obesity ; Obesity - drug therapy ; Obesity - metabolism ; Oligosaccharides - administration & dosage ; Prebiotics ; Rats ; Rats, Sprague-Dawley ; Rodents ; Satiation ; Weight control</subject><ispartof>Obesity (Silver Spring, Md.), 2015-04, Vol.23 (4), p.769-778</ispartof><rights>2015 The Obesity Society</rights><rights>2015 The Obesity Society.</rights><rights>Copyright Blackwell Publishing Ltd. Apr 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4547-9e0c86d3442b9b7bfbeebee5eb091a1b9ba6f9fdf06ec8d1f4f33ab8e9d023933</citedby><cites>FETCH-LOGICAL-c4547-9e0c86d3442b9b7bfbeebee5eb091a1b9ba6f9fdf06ec8d1f4f33ab8e9d023933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Foby.21017$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Foby.21017$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25820256$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cluny, Nina L.</creatorcontrib><creatorcontrib>Eller, Lindsay K.</creatorcontrib><creatorcontrib>Keenan, Catherine M.</creatorcontrib><creatorcontrib>Reimer, Raylene A.</creatorcontrib><creatorcontrib>Sharkey, Keith A.</creatorcontrib><title>Interactive effects of oligofructose and obesity predisposition on gut hormones and microbiota in diet‐induced obese rats</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>Objective
Oligofructose (OFS) is a prebiotic that reduces energy intake and fat mass via changes in gut satiety hormones and microbiota. The effects of OFS may vary depending on predisposition to obesity. The aim of this study was to examine the effect of OFS in diet‐induced obese (DIO) and diet‐resistant (DR) rats.
Methods
Adult, male DIO, and DR rats were randomized to: high‐fat/high‐sucrose (HFS) diet or HFS diet + 10% OFS for 6 weeks. Body composition, food intake, gut microbiota, plasma gut hormones, and cannabinoid CB1 receptor expression in the nodose ganglia were measured.
Results
OFS reduced body weight, energy intake, and fat mass in both phenotypes (P < 0.05). Select gut microbiota differed in DIO versus DR rats (P < 0.05), the differences being eliminated by OFS. OFS did not modify plasma ghrelin or CB1 expression in nodose ganglia, but plasma levels of GIP were reduced and PYY were elevated (P < 0.05) by OFS.
Conclusions
OFS was able to reduce body weight and adiposity in both prone and resistant obese phenotypes. OFS‐induced changes in gut microbiota profiles in DIO and DR rats, along with changes in gut hormone levels, likely contribute to the sustained lower body weights.</description><subject>Adiposity - drug effects</subject><subject>Animals</subject><subject>Body Composition - drug effects</subject><subject>Body Weight - drug effects</subject><subject>Diet</subject><subject>Dietary Fats - administration & dosage</subject><subject>Eating - drug effects</subject><subject>Gastrointestinal Hormones - metabolism</subject><subject>Ghrelin</subject><subject>Glucagon-Like Peptide 1 - metabolism</subject><subject>Hormones</subject><subject>Male</subject><subject>Microbiota</subject><subject>Obesity</subject><subject>Obesity - drug therapy</subject><subject>Obesity - metabolism</subject><subject>Oligosaccharides - administration & dosage</subject><subject>Prebiotics</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rodents</subject><subject>Satiation</subject><subject>Weight control</subject><issn>1930-7381</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10c1KHTEYBuAgSo_VLryBEnDTLs4xmcxMJkuVVg8IbhR0NeTny2lkZnJMMi2HbnoJvUavxOioC0H4ID88vCS8CB1QsqCEFEdebRYFJZRvoV0qGJlzJm623_YNnaHPMd4RUtakop_QrKiaghRVvYv-LocEQerkfgMGa0GniL3FvnMrb8Ook4-A5WCwVxBd2uB1AOPi2ueD8wPOsxoT_uVD7weIz7R3OnjlfJLYDdg4SA___rvBjBqmHMBBpriPdqzsInx5WffQ9c8fV6fn84vLs-Xp8cVcl1XJ5wKIbmrDyrJQQnFlFUCeChQRVNJ8J2srrLGkBt0YakvLmFQNCEMKJhjbQ9-m3HXw9yPE1PYuaug6OYAfY0vrmouaCM4zPXxH7_wYhvy6rHjDC0Z4mdX3SeVvxhjAtuvgehk2LSXtUyNtbqR9biTbry-Jo-rBvMnXCjI4msAf18Hm46T28uR2inwELg6ZVA</recordid><startdate>201504</startdate><enddate>201504</enddate><creator>Cluny, Nina L.</creator><creator>Eller, Lindsay K.</creator><creator>Keenan, Catherine M.</creator><creator>Reimer, Raylene A.</creator><creator>Sharkey, Keith A.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201504</creationdate><title>Interactive effects of oligofructose and obesity predisposition on gut hormones and microbiota in diet‐induced obese rats</title><author>Cluny, Nina L. ; Eller, Lindsay K. ; Keenan, Catherine M. ; Reimer, Raylene A. ; Sharkey, Keith A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4547-9e0c86d3442b9b7bfbeebee5eb091a1b9ba6f9fdf06ec8d1f4f33ab8e9d023933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adiposity - drug effects</topic><topic>Animals</topic><topic>Body Composition - drug effects</topic><topic>Body Weight - drug effects</topic><topic>Diet</topic><topic>Dietary Fats - administration & dosage</topic><topic>Eating - drug effects</topic><topic>Gastrointestinal Hormones - metabolism</topic><topic>Ghrelin</topic><topic>Glucagon-Like Peptide 1 - metabolism</topic><topic>Hormones</topic><topic>Male</topic><topic>Microbiota</topic><topic>Obesity</topic><topic>Obesity - drug therapy</topic><topic>Obesity - metabolism</topic><topic>Oligosaccharides - administration & dosage</topic><topic>Prebiotics</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rodents</topic><topic>Satiation</topic><topic>Weight control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cluny, Nina L.</creatorcontrib><creatorcontrib>Eller, Lindsay K.</creatorcontrib><creatorcontrib>Keenan, Catherine M.</creatorcontrib><creatorcontrib>Reimer, Raylene A.</creatorcontrib><creatorcontrib>Sharkey, Keith A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cluny, Nina L.</au><au>Eller, Lindsay K.</au><au>Keenan, Catherine M.</au><au>Reimer, Raylene A.</au><au>Sharkey, Keith A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interactive effects of oligofructose and obesity predisposition on gut hormones and microbiota in diet‐induced obese rats</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2015-04</date><risdate>2015</risdate><volume>23</volume><issue>4</issue><spage>769</spage><epage>778</epage><pages>769-778</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><abstract>Objective
Oligofructose (OFS) is a prebiotic that reduces energy intake and fat mass via changes in gut satiety hormones and microbiota. The effects of OFS may vary depending on predisposition to obesity. The aim of this study was to examine the effect of OFS in diet‐induced obese (DIO) and diet‐resistant (DR) rats.
Methods
Adult, male DIO, and DR rats were randomized to: high‐fat/high‐sucrose (HFS) diet or HFS diet + 10% OFS for 6 weeks. Body composition, food intake, gut microbiota, plasma gut hormones, and cannabinoid CB1 receptor expression in the nodose ganglia were measured.
Results
OFS reduced body weight, energy intake, and fat mass in both phenotypes (P < 0.05). Select gut microbiota differed in DIO versus DR rats (P < 0.05), the differences being eliminated by OFS. OFS did not modify plasma ghrelin or CB1 expression in nodose ganglia, but plasma levels of GIP were reduced and PYY were elevated (P < 0.05) by OFS.
Conclusions
OFS was able to reduce body weight and adiposity in both prone and resistant obese phenotypes. OFS‐induced changes in gut microbiota profiles in DIO and DR rats, along with changes in gut hormone levels, likely contribute to the sustained lower body weights.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25820256</pmid><doi>10.1002/oby.21017</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Obesity (Silver Spring, Md.), 2015-04, Vol.23 (4), p.769-778 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content |
| subjects | Adiposity - drug effects Animals Body Composition - drug effects Body Weight - drug effects Diet Dietary Fats - administration & dosage Eating - drug effects Gastrointestinal Hormones - metabolism Ghrelin Glucagon-Like Peptide 1 - metabolism Hormones Male Microbiota Obesity Obesity - drug therapy Obesity - metabolism Oligosaccharides - administration & dosage Prebiotics Rats Rats, Sprague-Dawley Rodents Satiation Weight control |
| title | Interactive effects of oligofructose and obesity predisposition on gut hormones and microbiota in diet‐induced obese rats |
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